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Quelle théorie de la justice pour l’épigénétique?

Published online by Cambridge University Press:  28 July 2015

CAROLINE GUIBET LAFAYE*
Affiliation:
Centre Maurice Halbwachs, CNRS (Paris)

Abstract

Epigenetics reveals the biological mechanisms underlying the reproduction and even the transmission of social inequalities in health. It also emphasizes the complexity of factors involved in the development of some diseases. This complexity raises new difficulties for theories of justice. Is the equal opportunities theory the most appropriate to solve these difficulties? I demonstrate that epigenetics requires a multifactor model of justice—one that is grounded on principles of fairness, impartiality, and environmental and intergenerational justice. Depending on the point of view assumed (i.e., individual, population-based, or intergenerational), the relevant principle of justice is different.

L’épigénétique dévoile les mécanismes biologiques sous-jacents à la reproduction, voire à la transmission des inégalités sociales de santé, et souligne la complexité des facteurs intervenant dans le développement de certaines pathologies. Cette complexité semble poser des difficultés inédites aux théories de la justice. Nous dessinons les contours d’une «justice épigénétique» en appréhendant d’abord les questions que l’épigénétique pose aux théories de la justice distributive. Le modèle de l’égalité des chances est-il le plus approprié pour saisir ces questions? Nous montrons que l’épigénétique ne peut être pensée qu’à partir d’un modèle de justice plurifactoriel. Selon la perspective adoptée (individuelle, populationnelle, intergénérationnelle), le principe de justice pertinent est distinct.

Type
Articles
Copyright
Copyright © Canadian Philosophical Association 2015 

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References

Références bibliographiques

Agarwal, Sharad et Porritt, Felicity 2008 «Les inégalités tuent à grande échelle», Communiqué de presse, Organisation mondiale de la santé (OMS). En ligne : <http://www.who.int/mediacentre/news/releases/2008/pr29/fr/>.Google Scholar
Barker, D. J. P. 1991 «The Fetal and Infant Origins of Inequalities in Health in Britain», Journal of Public Health Medicine, vol. 13, no2, p. 6468.Google Scholar
Barry, Brian 1989 «Justice as Reciprocity», dans Liberty and Justice, Oxford, Oxford University Press, p. 211241.Google Scholar
Bjornsson, Hans T., Fallin, M. Daniele et Feinberg, Andrew P. 2004 «An Integrated Epigenetic and Genetic Approach to Common Human Disease», Trends in Genetics, vol. 20, no8, p. 350358.CrossRefGoogle Scholar
Blanchon, Davidet al. 2009 «Comprendre et construire la justice environnementale», Annales de géographie, nos665666, p. 3560.CrossRefGoogle Scholar
Boorse, Christopher 1977 «Health as a Theoretical Concept»,Philosophy of Science, vol. 44, no4, p. 542573.CrossRefGoogle Scholar
Bradley, Robert H. et Corwyn, Robert F. 2002 «Socioeconomic Status and Child Development», Annual Review of Psychology, vol. 53, no1, p. 371399.CrossRefGoogle Scholar
Brunner, Eric 1997 «Socioeconomic Determinants of Health — Stress and the Biology of Inequality», British Medical Journal, vol. 314, no7092, p. 14721476.CrossRefGoogle Scholar
Brundtland, G.H.et al. 1987 Our Common Future, Oxford/NewYork (NY), Oxford University Press.Google Scholar
Buchanan, Allen, Brock, Dan W., Daniels, Norman et Wikler, Daniel 2000 From Chance to Choice, Genetics and Justice, New York (NY), Cambridge University Press.CrossRefGoogle Scholar
Chadwick, Ruth et O’Connor, Alan 2013 «Epigenetics and Personalized Medicine: Prospects and Ethical Issues», Personalized Medicine, vol. 10, no5, p. 463471.CrossRefGoogle Scholar
Chang, Jen-Chiehet al. 2012 «Perinatal Gene-gene and Gene-environment Interactions on IgE Production and Asthma Development», Clinical and Developmental Immunology, p. 270869.Google Scholar
Clark, Lara P.et al. 2014 «National Patterns in Environmental Injustice and Inequality: Outdoor NO2 Air Pollution in the United States», PLOS ONE, vol. 9, no4, p. e94431.CrossRefGoogle Scholar
Daniels, Norman 2008 Just Health: Meeting Health Needs Fairly, Cambridge, Cambridge University Press.Google Scholar
Darnaudery, Muriel et Maccari, Stefania 2008 «Epigenetic Programming of the Stress Response in Male and Female Rats by Prenatal Restraint Stress», Brain Research Review, vol. 57, no2, p. 571585.CrossRefGoogle Scholar
Davey Smith, George 2011 «Epidemiology, Epigenetics and the “Gloomy Prospect”: Embracing Randomness in Population Health Research and Practice», International Journal of Epidemiology, vol. 40, p. 537562.CrossRefGoogle Scholar
Davey Smith, George 2012 «Epigenesis for Epidemiologists: Does Evo-devo Have Implications for Population Health Research and Practice?», International Journal of Epidemiology, vol. 41, no1, p. 236247.CrossRefGoogle Scholar
de Shalit, Avner 1995 Why Posterity Matters. Environmental Policies and Future Generations, Londres, Routledge, p. 9699.Google Scholar
Dupras, Charles, Ravitsky, Vardit et Williams-Jones, Bryn 2014 «Epigenetics and the Environment in Bioethics», Bioethics, vol. 28, no7, p. 327334.CrossRefGoogle Scholar
Evans, Gary W. 2004 «The Environment of Childhood Poverty», American Psychologist, vol. 59, no2, p. 7792.CrossRefGoogle Scholar
Evans, G. W. et Kim, P. 2010 «Multiple Risk Exposure as a Potential Explanatory Mechanism for the Socioeconomic Status-health Gradient», Annalls of the New York Academy of Science, vol. 1186, p. 174189.CrossRefGoogle Scholar
Fish, E.W.et al. 2004 «Epigenetic Programming of Stress Responses Through Variations in Maternal Care», Annals of the New York Academy of Science, vol. 1036, p. 167180.CrossRefGoogle Scholar
Fraser, Nancy 2001 «Recognition Without Ethics?», Theory, Culture and Society, vol. 18, nos23, p. 2142.CrossRefGoogle Scholar
Gabory, Anne et Dandolo, Luisa 2005 «Épigénétique et développement : l’empreinte parentale», M/S : médecine sciences, vol. 21, n° 4, p. 390395.Google Scholar
Gaspart, Frédéric et Gosseries, Axel 2007 «Are Generational Savings Unjust?», Politics, Philosophy & Economics, vol. 6, no2, p. 193217.CrossRefGoogle Scholar
Giroux, Élodie 2009 «Définir objectivement la santé : une évaluation du concept bio-statistique de Boorse à partir de l’épidémiologie moderne», Revue philosophique de la France et de l’étranger, tome 134, no1, p. 3558.CrossRefGoogle Scholar
Gluckman, Peter D.et al. 2008 «Mechanisms of Disease: Effect of In Utero and Early-Life Conditions on Adult Health and Disease», New England Journal of Medicine, vol. 359, p. 6173.CrossRefGoogle Scholar
Gluckman, Peter D.et al. 2009 «Epigenetic Mechanisms that Underpin Metabolic and Cardiovascular Diseases», Nature Reviews Endocrinology, vol. 5, no7, p. 401408.CrossRefGoogle Scholar
Gluckman, Peter D., Hanson, Mark A. et Low, Felicia M. 2011 «The Role of Developmental Plasticity and Epigenetics in Human Health», Birth Defects Research Part C: Embryo Today, vol. 93, no1, p. 1218.CrossRefGoogle Scholar
Gosseries, Axel 2008 «Les théories de la justice intergénérationnelle. Synopsis à l’usage des durabilistes pressés», Raison publique, no8, p. 729.Google Scholar
Gosseries, Axel 2010 «Une métaphore de la justice intergénérationnelle», Regards croisés sur l’économie, no7, p. 193202.CrossRefGoogle Scholar
Griffin, James 1986 Well-being. Its Meaning, Measurement and Moral Signifiance, Oxford, Oxford Clarendon Press.Google Scholar
Guibet Lafaye, Caroline 2014 «L’épigénétique : pour de nouvelles politiques de santé?», Humanistyka i Przyrodoznawstwo, no20, p. 422.Google Scholar
Guibet Lafaye, Caroline 2015 «Ethical Issues Raised by Research in Epigenetics», Critical Review of International Social and Political Philosophy [à paraître].Google Scholar
Hackman, D. M. et Farah, M. J. 2009 «Socioeconomic Status and the Developing Brain», Trends in Cognitive Science, vol. 13, p. 6573.CrossRefGoogle Scholar
Hedlund, Maria 2012 «Epigenetic Responsibility», Medicine Studies, no3, p. 171183.CrossRefGoogle Scholar
Herceg, Zdenko et Hainaut, Pierre 2007 «Genetic and Epigenetic Alterations as Biomarkers for Cancer Detection, Diagnosis and Prognosis», Molecular Oncology, vol. 1, no1, p. 2641.CrossRefGoogle Scholar
Hook, Cayce J.et al. 2013 «Le statut socioéconomique et le développement des fonctions exécutives», dans R.E. Tremblay et al., dir., Encyclopédie sur le développement des jeunes enfants [en ligne], CEDJE, RSC-DJE.Google Scholar
Ji, Hong et Hershey, Gurjit K. K. 2012 «Genetic and Epigenetic Influence on the Response to Environmental Particulate Matter», Journal of Allergy and Clinical Immunology, vol. 129, p. 3341.CrossRefGoogle Scholar
Junien, Claudineet al. 2005 «Epigénomique nutritionnelle du syndrome métabolique», Médecine et Science, vol. 21, no4, p. 396404.CrossRefGoogle Scholar
Junien, Claudine 2011 «Les déterminants précoces de la santé et des maladies : nutrition et épigénétique», Bulletin de l’Académie nationale de médecine, tome 195, p. 511527.CrossRefGoogle Scholar
Khan, Fazal 2010 «Preserving Human Potential as Freedom: A Framework for Regulating Epigenetic Harms», Health Matrix, vol. 20, no2, p. 259323.Google Scholar
Kim, Sei-Hill et Anne Willis, L. 2007 «Talking About Obesity: News Framing of Who Is Responsible for Causing and Fixing the Problem», Journal of Health Communication, vol. 12, p. 359376.CrossRefGoogle Scholar
Latham, Keith E., Sapienza, Carmen et Engel, Nora 2012 «The Epigenetic Lorax: Gene-environment Interactions in Human Health», Epigenomics, vol. 4, no4, p. 383402.CrossRefGoogle Scholar
Lipina, Sebastian J. et Colombo, Jorge A. 2009 Poverty and Brain Development During Childhood: An Approach from Cognitive Psychology and Neuroscience, Washington (DC), American Psychological Association.Google Scholar
Lipina, Sebastian J. et Posner, Michael I. 2012 «The Impact of Poverty on the Development of Brain Networks», Frontiers in Human Neuroscience, vol. 6, art. 238, p. 112.CrossRefGoogle Scholar
Loi, Michele, del Davio, Lorenzo et Stupka, Elia 2013 «Social Epigenetics and Equality of Opportunity», Public Health Ethics, vol. 6, no2, p. 142153.CrossRefGoogle Scholar
Lumey, L. H. 1992 «Decreased Birthweights in Infants After Maternal In Utero Exposure to the Dutch Famine of 1944–1945», Paediatric and Perinatal Epidemiology, vol. 6, no2, p. 240253.CrossRefGoogle Scholar
Magnus, David 2012 «Le concept de maladie génétique», dans Élodie Giroux et Maël Lemoine, dir., Philosophie de la médecine, Paris, Vrin.Google Scholar
McGowan, P. O.et al. 2009 «Epigenetic Regulation of the Glucocorticoid Receptor in Human Brain Associates With Childhood Abuse», Nature Neuroscience, vol. 12, no3, p. 342348.CrossRefGoogle Scholar
Morgan, Daniel K. et Whitelaw, Emma 2008 «The Case for Transgenerational Epigenetic Inheritance in Humans», Mammalian Genome, vol. 19, p. 394397.CrossRefGoogle Scholar
Niewöhner, Jörg 2011 «Epigenetics: Embedded Bodies and the Molecularisation of Biography and Milieu», BioSocieties, vol. 6, p. 279298.CrossRefGoogle Scholar
Ober, Carole et Vercelli, Donata 2011 «Gene-environment Interactions in Human Disease: Nuisance or Opportunity?», Trends in Genetics, vol. 27, no3, p. 107115.CrossRefGoogle Scholar
Okereke, Chukwumerije 2006 «Global Environmental Sustainability: Intragenerational Equity and Conceptions of Justice in Multilateral Environmental Regimes», Geoforum, vol. 37, no5, p. 725738.CrossRefGoogle Scholar
Pembrey, Marcus E.et al. 2006 «Sex-specific, Male-line Transgenerational Responses in Humans», European Journal of Human Genetics, vol. 14, no1, p. 159166.CrossRefGoogle Scholar
Préteceille, Edmond 2006 «La ségrégation sociale a-t-elle augmenté?», Sociétés Contemporaines, no 62, p. 6993.CrossRefGoogle Scholar
Raizada, Rajeev D. et Kishiyama, Mark M. 2010 «Effects of Socioeconomic Status on Brain Development, and How Cognitive Neuroscience May Contribute to Levelling the Playing Field», Froniers in Human Neuroscience, vol. 4, no3.Google Scholar
Rawls, John 1971 Theory of Justice, Cambridge (MA), Belknap Press of Harvard University Press. Trad. française : Théorie de la justice, Paris, Seuil, 1987.CrossRefGoogle Scholar
Rawls, John 1993 Political Liberalism, New York (NY), Columbia University Press.Google Scholar
Rawls, John 2001 Justice as Fairness. A Restatement, Cambridge (MA) et Londres, Harvard University Press.CrossRefGoogle Scholar
Régnier, Faustine 2009 «Obésité, goûts et consommation. Intégration des normes d’alimentation et appartenance sociale», Revue française de sociologie, vol. 50, no4, p. 747773.CrossRefGoogle Scholar
Rose, Geoffrey 1985 «Sick Individuals and Sick Populations», International Journal of Epidemiology, vol. 14, no1, p. 3238.CrossRefGoogle Scholar
Sen, Amartya K. 1985 Commodities and Capabilities, Amsterdam, North-Holland.Google Scholar
Skinner, Michael K.et al. 2008 «Transgenerational Epigenetic Programming of the Brain Transcriptome and Anxiety Behavior», PLOS One, vol. 3, no11, p. e3745.CrossRefGoogle Scholar
Stapleton, G.et al. 2013 «Equity in Public Health: An Epigenetic Perspective», Public Health Genomics, vol. 16, no4, p. 135144.CrossRefGoogle Scholar
Stein, Aryeh D. et Lumey, L. H. 2002 «The Relationship Between Maternal and Offspring Birth Weights After Maternal Prenatal Famine Exposure: the Dutch Famine Birth Cohort Study», Human Biology, vol. 72, no4, p. 641654.Google Scholar
Szyf, Moshe 2007 «The Dynamic Epigenome and Its Implications in Toxicology», Journal of Toxicological Science, vol. 100, no1, p. 723.CrossRefGoogle Scholar
Tang, Wan-yee et Ho, Shuk-mei 2007 «Epigenetic Reprogramming and Imprinting in Origins of Disease», Reviews in Endocrine and Metabolic Disorders, vol. 8, no2, p. 173182.CrossRefGoogle Scholar
Theys, J. 2000 «Quand inégalités sociales et inégalités écologiques se cumulent. L’exemple du SELA», Note du CPVS, no 13, MELT-DRAST.Google Scholar
van Speybroeck, Linda 2002 «Philosophers and Biologists Exploring Epigenetics», Biology and Philosophy, vol. 17, n° 5, p. 743746.CrossRefGoogle Scholar
Vandermotten, Christian 2007 «Territoires et inégalités», dans Pierre Cornut, Tom Bauler et Edwin Zaccaï, dir., Environnement et inégalités sociales, Bruxelles, Éditions de l’Université de Bruxelles, p. 149156.Google Scholar
Venkatapuram, Sridhar 2011 Health Justice: an Argument From The Capabilities Approach, Cambridge, Polity Press.Google Scholar
Wallace, Douglas C. 2010 «Bioenergetics and the Epigenome: Interface Between the Environment and Genes in Common Diseases», Developmental Disabilities Research Reviews, vol. 16, no2, p. 114119.CrossRefGoogle Scholar
Weaver, Ian C. G.et al. 2004 «Epigenetic Programming by Maternal Behavior», Nature Neuroscience, vol. 7, p. 847854.CrossRefGoogle Scholar
Weaver, Ian C.G. 2007 «Epigenetic Programming by Maternal Behavior and Pharmacological Intervention. Nature Versus Nurture: Let’s Call the Whole Thing Off», Epigenetics, vol. 2, p. 2228.CrossRefGoogle Scholar
Wild, Christopher Paul 2012 «The Exposome: From Concept to Utility», International Journal of Epidemiology, vol. 41, no1, p. 2432.CrossRefGoogle Scholar