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Maternal herpes labialis in pregnancy and neural tube defects

Published online by Cambridge University Press:  12 July 2006

Bente Nørgård ,
Mette Nørgaard ,
Andrew E Czeizel ,
Erzsébet Puhó  and
Henrik T Sørensen
Bente Nørgård
Affiliation:
Department of Clinical Epidemiology, Aarhus University Hospital, Denmark.
Mette Nørgaard
Affiliation:
Department of Clinical Epidemiology, Aarhus University Hospital, Denmark.
Andrew E Czeizel
Affiliation:
The Foundation for the Community Control of Hereditary Diseases, Hungary.
Erzsébet Puhó
Affiliation:
Department of Human Genetics and Teratology, National Centre for Epidemiology, Budapest, Hungary.
Henrik T Sørensen
Affiliation:
Department of Clinical Epidemiology, Aarhus University Hospital, Denmark.
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Abstract

According to previous case reports, some congenital abnormalities (CAs) of the brain, such as microcephaly, are a result of intrauterine herpes simplex virus infection. A population-based case–control study was conducted to determine the risk of neural tube defects (NTDs) after maternal herpes labialis infection during pregnancy. Data were taken from the Hungarian Case–Control Surveillance of Congenital Abnormalities from 1980 to 1996, which included 1202 children with NTDs and 21641 comparison children with CAs other than NTDs. The adjusted relative risks (odds ratio [OR]) for NTDs associated with maternal herpes labialis in the first trimester of pregnancy was OR 1.19 (95% confidence interval [CI] 0.68–2.06), and in the entire pregnancy was OR 0.94 (95% CI 0.61–1.44). Self-reported maternal herpes labialis during pregnancy was not associated with a substantially increased risk of NTDs in infants.

Type
Original Articles
Information
Developmental Medicine and Child Neurology , Volume 48 , Issue 8 , August 2006 , pp. 674 - 676
Copyright
2006 Mac Keith Press

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