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Early motor development in young children with 22q.11 deletion syndrome and a conotruncal heart defect

Published online by Cambridge University Press:  16 November 2005

Ann Swillen
Affiliation:
Department of Human Genetics, University Hospital Gasthuisberg, University of Leuven, Belgium. Department of Kinesiology and Rehabilitation Sciences, University Hospital Gasthuisberg, University of Leuven, Belgium.
Hilde Feys
Affiliation:
Department of Kinesiology and Rehabilitation Sciences, University Hospital Gasthuisberg, University of Leuven, Belgium.
Tamara Adriaens
Affiliation:
Department of Kinesiology and Rehabilitation Sciences, University Hospital Gasthuisberg, University of Leuven, Belgium.
Loes Nelissen
Affiliation:
Department of Kinesiology and Rehabilitation Sciences, University Hospital Gasthuisberg, University of Leuven, Belgium.
Luc Mertens
Affiliation:
Department of Pediatric Cardiology, University Hospital Gasthuisberg, University of Leuven, Belgium.
Marc Gewillig
Affiliation:
Department of Pediatric Cardiology, University Hospital Gasthuisberg, University of Leuven, Belgium.
Koen Devriendt
Affiliation:
Department of Human Genetics, University Hospital Gasthuisberg, University of Leuven, Belgium.
Jean-Pierre Fryns
Affiliation:
Department of Human Genetics, University Hospital Gasthuisberg, University of Leuven, Belgium.
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Abstract

Velocardiofacial syndrome is identified by a submicroscopic deletion of chromosome 22q.11 (del22q.11). This study presents data on the early motor development and behaviour of 11 children (8 males, 3 females) with del22q.11 (mean age 41mo, SD 9.7mo) with a congenital heart defect. To control for the impact of the congenital heart defect, a control group of 19 children (15 males, 4 females; mean age 46mo, SD 9mo) with the same types of congenital heart defects but without del22q.11 was selected. Motor development in both groups was measured with the Peabody Developmental Motor Scales-2. Behaviour was assessed with the Child Behaviour Checklist. Children with del22q.11 scored significantly lower (p<0.05) on motor performance than the children of the control group. Most deficient motor skills were found for the subtests Locomotion and Stationary. On the behaviour questionnaire, a statistically significant (p<0.05) difference between the two groups was found only for the subscale Withdrawn. These data reveal a significant motor delay in many young children with del22q.11, which is not caused by the presence of a congenital heart defect or by behavioural features.

Type
Original Articles
Copyright
© 2005 Mac Keith Press

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