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Defining risk heterogeneity for internalizing symptoms among children of alcoholic parents

Published online by Cambridge University Press:  23 January 2008

Andrea M. Hussong ,
David B. Flora ,
Patrick J. Curran ,
Laurie A. Chassin  and
Robert A. Zucker
Andrea M. Hussong*
Affiliation:
University of North Carolina at Chapel Hill
David B. Flora
Affiliation:
York University
Patrick J. Curran
Affiliation:
University of North Carolina at Chapel Hill
Laurie A. Chassin
Affiliation:
Arizona State University
Robert A. Zucker
Affiliation:
University of Michigan
*
Address correspondence and reprint requests to: Andrea Hussong, CB#3270 Davie Hall, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599-3270; E-mail: hussong@unc.edu.
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Abstract

Adopting a developmental epidemiology perspective, the current study examines sources of risk heterogeneity for internalizing symptomatology among children of alcoholic parents (COAs). Parent-based factors, including comorbid diagnoses and the number of alcoholic parents in the family, as well as child-based factors, namely child gender, formed the indicators of heterogeneity. Following a novel approach to cross-study methods, we present a three-stage analysis involving measurement development using item response theory, examination of study effects on latent trajectories over time using latent curve modeling, and prediction of these latent trajectories testing our theoretically derived hypotheses in two longitudinal investigations across both mother- and self-reported symptomatology. Specifically, we replicated previous findings that parent alcoholism has a unique effect on child internalizing symptoms, above and beyond those of both parent depression and antisocial personality disorder. However, we also found important subgroup differences, explaining heterogeneity within COAs' risk profile in terms of the number of alcoholic parents in the family, comorbid diagnoses for the alcoholic parent and, for self-reported symptoms, child gender. Such factors serve to refine the definition of risk among COAs, suggesting a more severely impaired target group for preventive interventions, identifying the significance of familial alcoholism in individual differences underlying internalizing symptoms over time, and further specifying the distal risk matrix for an internalizing pathway to alcohol involvement.

Type
Research Article
Information
Development and Psychopathology , Volume 20 , Issue 1 , Winter 2008 , pp. 165 - 193
Copyright
Copyright © Cambridge University Press 2008

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Footnotes

This work was supported by Grants R01 DA15398 (to A.M.H.), R37 AA 07065 (to R.A.Z.), R01 AA16213 (to L.A.C.), and R01 DA13148 (to P.J.C.). We thank the Centre for Addictions Research in British Columbia at the University of Victoria and the Reynolds Competitive Study Leave program for their support, and we acknowledge the contributions of Michael Edwards, R. J. Wirth, and Daniel Serrano.

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