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Pupillary and affective responses to maternal feedback and the development of borderline personality disorder symptoms

Published online by Cambridge University Press:  25 October 2016

Lori N. Scott*
Affiliation:
University of Pittsburgh School of Medicine
Maureen Zalewski
Affiliation:
University of Oregon
Joseph E. Beeney
Affiliation:
University of Pittsburgh School of Medicine
Neil P. Jones
Affiliation:
University of Pittsburgh School of Medicine
Stephanie D. Stepp
Affiliation:
University of Pittsburgh School of Medicine
*
Address correspondence and reprint requests to: Lori N. Scott, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213; E-mail: scottln2@upmc.edu.

Abstract

Etiological models propose that a biological vulnerability to emotional reactivity plays an important role in the development of borderline personality disorder (BPD). However, the physiological and phenomenological components of emotional reactivity that predict the course of BPD symptoms in adolescence are poorly understood. This prospective study examines pupillary and affective responses to maternal feedback as predictors of BPD symptom development in adolescent girls over 18 months. Fifty-seven 16-year-old girls completed a laboratory task in which they heard recorded clips of their own mothers making critical or praising statements about them, as well as neutral statements that did not pertain to them. Changes in girls’ pupil dilation and subjective affect were assessed throughout the task. The results demonstrated that greater pupillary response to maternal criticism predicted increases in BPD symptoms over time. In addition, greater pupillary and positive affective responses to maternal praise were associated with higher BPD symptoms at age 16 and faster decreases in BPD symptoms over time, but only among girls who heard clips that were rated by independent observers as less praising. The results suggest that emotional reactivity can serve as either a risk or a protective factor depending on context, with differential effects of reactivity to criticism versus praise.

Type
Regular Articles
Copyright
Copyright © Cambridge University Press 2016 

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Footnotes

This research and the efforts of the authors were supported by grants from the National Institute of Mental Health (K01 MH086713, Principal Investigator [PI] S.D.S.; R01 MH101088, PI S.D.S.; R01 MH056630, PI R. Loeber; K01 MH101289, PI L.N.S.; K01 MH086811, PI N.P.J.; F32 MH102895, PI J.E.B.), the National Institute on Drug Abuse (R01 DA012237, PI T. Chung), and by funding from the Office of Juvenile Justice and Delinquency Prevention (2013-JF-FX-0058, PIs A. E. Hipwell and S.D.S.), the FISA Foundation (PI R. Loeber), and the Falk Fund (PI R. Loeber).

References

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Press.Google Scholar
Aston-Jones, G., & Cohen, J. D. (2005). An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance. Annual Review of Neuroscience, 28, 403450. doi:10.1146/annurev.neuro.28.061604.135709 CrossRefGoogle ScholarPubMed
Baer, R. A., Peters, J. R., Eisenlohr-Moul, T. A., Geiger, P. J., & Sauer, S. E. (2012). Emotion-related cognitive processes in borderline personality disorder: A review of the empirical literature. Clinical Psychology Review, 32, 359369. doi:10.1016/j.cpr.2012.03.002 CrossRefGoogle Scholar
Becker, D. F., Grilo, C. M., Edell, W. S., & McGlashan, T. H. (2002). Diagnostic efficiency of borderline personality disorder criteria in hospitalized adolescents: Comparison with hospitalized adults. American Journal of Psychiatry, 159, 20422047. doi:10.1176/appi.ajp.159.12.2042 CrossRefGoogle Scholar
Belsky, J. (2005). Differential susceptibility to rearing influences: An evolutionary hypothesis and some evidence. In Ellis, B. & Bjorklund, D. (Eds.), Origins of the social mind: Evolutionary psychology and child development (pp. 139163). New York: Guilford Press.Google Scholar
Berenson, K. R., Downey, G., Rafiaeli, E., Coifman, K. G., & Paquin, N. L. (2011). The rejection-rage contingency in borderline personality disorder. Journal of Abnormal Psychology, 120, 681690.CrossRefGoogle ScholarPubMed
Bornovalova, M. A., Hicks, B. M., Iacono, W. G., & McGue, M. (2009). Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: A longitudinal twin study. Development and Psychopathology, 21, 13351353. doi:10.1017/S0954579409990186 CrossRefGoogle Scholar
Bouret, S., & Sara, S. J. (2005). Network reset: A simplified overarching theory of locus coeruleus noradrenaline function. Trends in Neurosciences, 28, 574582. doi:10.1016/j.tins.2005.09.002 CrossRefGoogle Scholar
Boyce, W. T., & Ellis, B. J. (2005). Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity. Development and Psychopathology, 17, 271301. doi:10.1017/S0954579405050145 CrossRefGoogle Scholar
Bradley, R., Jenei, J., & Westen, D. (2005). Etiology of borderline personality disorder: Disentangling the contributions of intercorrelated antecedents. Journal of Nervous and Mental Disease, 193, 2431.CrossRefGoogle ScholarPubMed
Cavazzi, T., & Becerra, R. (2014). Psychophysiological research of borderline personality disorder: Review and implications for biosocial theory. Europe's Journal of Psychology, 10, 185203.CrossRefGoogle Scholar
Chabrol, H., Montovany, A., Ducongé, E., Kallmeyer, A., Mullet, E., & Leichsenring, F. (2004). Factor structure of the borderline personality inventory in adolescents. European Journal of Psychological Assessment, 20, 5965. doi:10.1027/1015-5759.20.1.59 CrossRefGoogle Scholar
Chanen, A. M., & Kaess, M. (2012). Developmental pathways to borderline personality disorder. Current Psychiatry Reports, 14, 4553. doi:10.1007/s11920-011-0242-y CrossRefGoogle ScholarPubMed
Chapman, A. L., Walters, K. N., & Dixon Gordon, K. L. (2014). Emotional reactivity to social rejection and negative evaluation among persons with borderline personality features. Journal of Personality Disorders, 28, 720733. doi:10.1521/pedi_2012_26_068 CrossRefGoogle ScholarPubMed
Crowell, S. E., Beauchaine, T. P., & Linehan, M. M. (2009). A biosocial developmental model of borderline personality: Elaborating and extending Linehan's theory. Psychological Bulletin, 135, 495510. doi:10.1037/a0015616 CrossRefGoogle ScholarPubMed
Crowell, S. E., & Yaptangco, M. (2013). Suicidal behaviours are common among US adolescents and are associated with mental health disorders. Evidence-Based Mental Health, 16, 106. doi:10.1136/eb-2013-101395 Google ScholarPubMed
Del Giudice, M., Ellis, B. J., & Shirtcliff, E. A. (2011). The adaptive calibration model of stress responsivity. Neuroscience & Biobehavioral Reviews, 35, 15621592. doi:10.1016/j.neubiorev.2010.11.007 CrossRefGoogle ScholarPubMed
Ellis, B. J., Del Giudice, M., & Shirtcliff, E. A. (2013). Beyond allostatic load: The stress response system as a mechanism of conditional adaptation. Child and Adolescent Psychopathology, 2, 251284.Google Scholar
Fonagy, P., Target, M., & Gergely, G. (2000). Attachment and borderline personality disorder: A theory and some evidence. Psychiatric Clinics of North America, 23, 103122. doi:10.1016/S0193-953X(05)70146-5 CrossRefGoogle ScholarPubMed
Fruzzetti, A. E., Shenk, C., & Hoffman, P. D. (2005). Family interaction and the development of borderline personality disorder: A transactional model. Development and Psychopathology, 17, 10071030.CrossRefGoogle Scholar
Glenn, C. R., & Klonsky, E. D. (2013). Reliability and validity of borderline personality disorder in hospitalized adolescents. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 22, 206211.Google Scholar
Grant, B. F., Chou, S. P., Goldstein, R. B., Huang, B., Stinson, F. S., Saha, T. D., … Ruan, W. J. (2008). Prevalence, correlates, disability, and comorbidity of DSM-IV borderline personality disorder: Results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. Journal of Clinical Psychiatry, 69, 533–450.CrossRefGoogle Scholar
Gratz, K. L., Rosenthal, M. Z., Tull, M. T., Lejuez, C. W., & Gunderson, J. G. (2010). An experimental investigation of emotional reactivity and delayed emotional recovery in borderline personality disorder: The role of shame. Comprehensive Psychiatry, 51, 272285. doi:10.1016/j.comppsych.2009.08.005 20399337 CrossRefGoogle ScholarPubMed
Gunderson, J. G., & Lyons-Ruth, K. (2008). BPD's interpersonal hypersensitivity phenotype: A gene–environment–developmental model. Journal of Personality Disorders, 22, 2241. doi:10.1521/pedi.2008.22.1.22 CrossRefGoogle ScholarPubMed
Ha, C., Balderas, J. C., Zanarini, M. C., Oldham, J., & Sharp, C. (2014). Psychiatric comorbidity in hospitalized adolescents with borderline personality disorder. Journal of Clinical Psychiatry, 75, e457e464. doi:10.4088/JCP.13m08696 CrossRefGoogle ScholarPubMed
Herpertz, S. C., Kunert, H. J., Schwenger, U. B., & Sass, H. (1999). Affective responsiveness in borderline personality disorder: A psychophysiological approach. American Journal of Psychiatry, 156, 15501556.CrossRefGoogle Scholar
Hooley, J. M., Gruber, S. A., Scott, L. A., Hiller, J. B., & Yurgelun-Todd, D. A. (2005). Activation in dorsolateral prefrontal cortex in response to maternal criticism and praise in recovered depressed and healthy control participants. Biological Psychiatry, 57, 809812. doi:10.1016/j.biopsych.2005.01.012 CrossRefGoogle Scholar
Jacob, G. A., Guenzler, C., Zimmermann, S., Scheel, C. N., Rusch, N., Leonhart, R., …  Lieb, K. (2008). Time course of anger and other emotions in women with borderline personality disorder: A preliminary study. Journal of Behavior Therapy and Experimental Psychiatry, 39, 391402. doi:10.1016/j.jbtep.2007.10.009 CrossRefGoogle ScholarPubMed
Jacob, G. A., Hellstern, K., Ower, N., Pillmann, M., Scheel, C. N., Rusch, N., & Lieb, K. (2009). Emotional reactions to standardized stimuli in women with borderline personality disorder: Stronger negative affect, but no differences in reactivity. Journal of Nervous and Mental Disease, 197, 808815. doi:10.1097/NMD.0b013e3181bea44d CrossRefGoogle ScholarPubMed
Jovev, M., Green, M., Chanen, A., Cotton, S., Coltheart, M., & Jackson, H. (2012). Attentional processes and responding to affective faces in youth with borderline personality features. Psychiatry Research, 199, 4450. doi:10.1016/j.psychres.2012.03.027 CrossRefGoogle ScholarPubMed
Keenan, K., Hipwell, A., Chung, T., Stepp, S., Stouthamer-Loeber, M., Loeber, R., & McTigue, K. (2010). The Pittsburgh Girls Study: Overview and initial findings. Journal of Clinical Child and Adolescent Psychology, 39, 506521. doi:10.1080/15374416.2010.486320 CrossRefGoogle ScholarPubMed
Kernberg, O. F. (1984). Severe personality disorders: Psychotherapeutic strategies. New Haven, CT: Yale University Press.Google Scholar
Koikegami, H., & Yoshida, K. (1953). Pupillary dilatation induced by stimulation of amygdaloid nuclei. Psychiatry and Clinical Neurosciences, 7, 109126.CrossRefGoogle Scholar
Kuo, J. R., & Linehan, M. M. (2009). Disentangling emotion processes in borderline personality disorder: Physiological and self-reported assessment of biological vulnerability, baseline intensity, and reactivity to emotionally evocative stimuli. Journal of Abnormal Psychology, 118, 531544. doi:10.1037/a0016392 CrossRefGoogle Scholar
Laeng, B., Sirois, S., & Gredebäck, G. (2012). Pupillometry: A window to the preconscious? Perspectives on Psychological Science, 7, 1827. doi:10.1177/1745691611427305 CrossRefGoogle ScholarPubMed
Lazarus, S. A., Cheavens, J. S., Festa, F., & Zachary Rosenthal, M. (2014). Interpersonal functioning in borderline personality disorder: A systematic review of behavioral and laboratory-based assessments. Clinical Psychology Review, 34, 193205. doi:10.1016/j.cpr.2014.01.007 CrossRefGoogle ScholarPubMed
Linehan, M. M. (1993). Cognitive-behavioral treatment of borderline personality disorder. New York: Guilford Press.Google ScholarPubMed
Lis, E., Greenfield, B., Henry, M., Guilé, J. M., & Dougherty, G. (2007). Neuroimaging and genetics of borderline personality disorder: A review. Journal of Psychiatry and Neuroscience, 32, 162.Google Scholar
Matusiewicz, A., Weaverling, G., & Lejuez, C. W. (2014). Emotion dysregulation among adolescents with borderline personality disorder. In Sharp, C. & Tackett, J. L. (Eds.), Handbook of borderline personality disorder in children and adolescents (pp. 177194). New York: Springer.CrossRefGoogle Scholar
Miller, A. L., Muehlenkamp, J. J., & Jacobson, C. M. (2008). Fact or fiction: Diagnosing borderline personality disorder in adolescents. Clinical Psychology Review, 28, 969981. doi:10.1016/j.cpr.2008.02.004 CrossRefGoogle ScholarPubMed
Miller, A. L., Rathus, J. H., & Linehan, M. M. (2007). Dialectical behavior therapy with suicidal adolescents. New York: Guilford Press.Google ScholarPubMed
Morey, L. C. (1991). Personality Assessment Inventory: Professional manual. Odessa, FL: Psychological Assessment Resources.Google Scholar
Pfohl, B., Blum, N., & Zimmerman, M. (1997). Structured interview for DSM–IV personality. Washington, DC: American Psychiatric Press.Google Scholar
Preacher, K. J., Curran, P. J., & Bauer, D. J. (2006). Computational tools for probing interactions in multiple linear regression, multilevel modeling, and latent curve analysis. Journal of Educational and Behavioral Statistics, 31, 437448. doi:10.3102/10769986031004437 CrossRefGoogle Scholar
Raizada, R. D., & Poldrack, R. A. (2007). Challenge-driven attention: Interacting frontal and brainstem systems. Frontiers in Human Neuroscience, 1, 3. doi:10.3389/neuro.09.003.2007 Google ScholarPubMed
Raudenbush, S. W., & Bryk, A. S. (2002). Hierarchical linear models: Applications and data analysis methods (2nd ed.). Thousand Oaks, CA: Sage.Google Scholar
Raudenbush, S. W., & Xiao-Feng, L. (2001). Effects of study duration, frequency of observation, and sample size on power in studies of group differences in polynomial change. Psychological Methods, 6, 387401. doi:10.1037/1082-989X.6.4.387 CrossRefGoogle ScholarPubMed
Rosenthal, M. Z., Gratz, K. L., Kosson, D. S., Cheavens, J. S., Lejuez, C. W., & Lynch, T. R. (2008). Borderline personality disorder and emotional responding: A review of the research literature. Clinical Psychology Review, 28, 7591. doi:10.1016/j.cpr.2007.04.001 CrossRefGoogle ScholarPubMed
Rosler, M., Retz, W., Yaqoobi, K., Burg, E., & Retz-Junginger, P. (2009). Attention deficit/hyperactivity disorder in female offenders: Prevalence, psychiatric comorbidity and psychosocial implications. European Archives of Psychiatry and Clinical Neuroscience, 259, 98105. doi:10.1007/s00406-008-0841-8 CrossRefGoogle ScholarPubMed
Sadikaj, G., Moskowitz, D. S., Russell, J. J., Zuroff, D. C., & Paris, J. (2013). Quarrelsome behavior in borderline personality disorder: Influence of behavioral and affective reactivity to perceptions of others. Journal of Abnormal Psychology, 122, 195207. doi:10.1037/a0030871 CrossRefGoogle Scholar
Scott, L. N., Levy, K. N., & Granger, D. A. (2013). Biobehavioral reactivity to social evaluative stress in women with borderline personality disorder. Personality Disorders: Theory, Research, and Treatment, 4, 91100. doi:10.1037/a0030117 CrossRefGoogle ScholarPubMed
Siegle, G. J., Ichikawa, N., & Steinhauer, S. (2008). Blink before and after you think: Blinks occur prior to and following cognitive load indexed by pupillary responses. Psychophysiology, 45, 679687. doi:10.1111/j.1469-8986.2008.00681.x CrossRefGoogle ScholarPubMed
Sieswerda, S., Arntz, A., Mertens, I., & Vertommen, S. (2007). Hypervigilance in patients with borderline personality disorder: Specificity, automaticity, and predictors. Behaviour Research and Therapy, 45, 10111024. doi:10.1016/j.brat.2006.07.012 CrossRefGoogle ScholarPubMed
Silk, J. S., Dahl, R. E., Ryan, N. D., Forbes, E. E., Axelson, D. A., Birmaher, B., & Siegle, G. J. (2007). Pupillary reactivity to emotional information in child and adolescent depression: Links to clinical and ecological measures. American Journal of Psychiatry, 164, 18731880. doi:10.1176/appi.ajp.2007.06111816 CrossRefGoogle ScholarPubMed
Silk, J. S., Stroud, L. R., Siegle, G. J., Dahl, R. E., Lee, K. H., & Nelson, E. E. (2012). Peer acceptance and rejection through the eyes of youth: Pupillary, eyetracking and ecological data from the Chatroom Interact task. Social Cognitive and Affective Neuroscience, 7, 93105. doi:10.1093/scan/nsr044 CrossRefGoogle ScholarPubMed
Stepp, S. D., Whalen, D. J., Scott, L. N., Zalewski, M., Loeber, R., & Hipwell, A. E. (2014). Reciprocal effects of parenting and borderline personality disorder symptoms in adolescent girls. Development and Psychopathology, 26, 361378. doi:10.1017/s0954579413001041 CrossRefGoogle ScholarPubMed
Stepp, S. D., Scott, L. N., Jones, N. P., Whalen, D. J., & Hipwell, A. E. (in press). Negative emotional reactivity as a marker of vulnerability in the development of borderline personality disorder symptoms. Development and Psychopathology.Google ScholarPubMed
Trull, T. J. (1995). Borderline personality disorder features in nonclinical young adults: I. Identification and validation. Psychological Assessment, 7, 3341. doi:10.1037/1040-3590.7.1.33 CrossRefGoogle Scholar
Trull, T. J., Jahng, S., Tomko, R. L., Wood, P. K., & Sher, K. J. (2010). Revised NESARC personality disorder diagnoses: Gender, prevalence, and comorbidity with substance dependence disorders. Journal of Personality Disorders, 24, 412426. doi:10.1521/pedi.2010.24.4.412 CrossRefGoogle ScholarPubMed
Trull, T. J., Useda, J. D., Conforti, K., & Doan, B. T. (1997). Borderline personality disorder features in nonclinical young adults: 2. Two-year outcome. Journal of Abnormal Psychology, 106, 307314.CrossRefGoogle ScholarPubMed
Vitale, J. E., & Newman, J. P. (2012). Affective startle modulation in incarcerated women with borderline personality disorder features. Personality Disorders: Theory, Research, and Treatment, 3, 155166. doi:10.1037/a0025554 CrossRefGoogle Scholar
von Ceumern-Lindenstjerna, I.-A., Brunner, R., Parzer, P., Mundt, C., Fiedler, P., & Resch, F. (2010a). Attentional bias in later stages of emotional information processing in female adolescents with borderline personality disorder. Psychopathology, 43, 2532.CrossRefGoogle ScholarPubMed
von Ceumern-Lindenstjerna, I. A., Brunner, R., Parzer, P., Mundt, C., Fiedler, P., & Resch, F. (2010b). Initial orienting to emotional faces in female adolescents with borderline personality disorder. Psychopathology, 43, 7987. doi:10.1159/000274176 CrossRefGoogle Scholar
Whalen, D. J., Scott, L. N., Jakubowski, K. P., McMakin, D. L., Hipwell, A. E., Silk, J. S., & Stepp, S. D. (2014). Affective behavior during mother-daughter conflict and borderline personality disorder severity across adolescence. Personality Disorders: Theory, Research, and Treatment, 5, 8896. doi:10.1037/per0000059 CrossRefGoogle Scholar
Wright, A. C. G., Zalewski, M., Hallquist, M. N., Hipwell, A. E., & Stepp, S. D. (2015). Developmental trajectories of borderline personality disorder symptoms and psychosocial functioning in adolescence. Journal of Personality Disorders.Google Scholar
Zanarini, M. C., Frankenburg, F. R., Hennen, J., & Silk, K. R. (2003). The longitudinal course of borderline psychopathology: 6-year prospective follow-up of the phenomenology of borderline personality disorder. American Journal of Psychiatry, 160, 274283.CrossRefGoogle Scholar
Zanarini, M. C., Horwood, J., Wolke, D., Waylen, A., Fitzmaurice, G., & Grant, B. F. (2011). Prevalence of DSM-IV borderline personality disorder in two community samples: 6,330 English 11-year-olds and 34,653 American adults. Journal of Personality Disorders, 25, 607619. doi:10.1521/pedi.2011.25.5.607 CrossRefGoogle ScholarPubMed
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