Depression and mania are common mental illnesses. Venlafaxine combined with Sweet Dream oral liquid is widely used in the treatment of these mental diseases as a drug therapy. However, the analysis of its efficacy is relatively limited.

100 middle school students diagnosed with depression and mania were recruited and randomly divided into test group and control group. The test group received Venlafaxine combined with Sweet Dream oral liquid, and the control group received placebo. SPSS23.0 software was used for data processing and statistical analysis.

After 8 weeks of treatment, symptoms of depression and mania were improved in both test and control groups. Depressive symptom scores decreased from 32.5±6.2 to 18.3±4.9 (P<0.001) in the test group and from 34.2±5.8 to 20.1±5.4 (P<0.001) in the control group. The score of mania symptoms decreased from 29.7±7.1 to 15.2±4.6 (P<0.001) in the test group and from 31.0±6.5 to 16.8±5.2 (P<0.001) in the control group. The test group showed a significant advantage in symptom improvement.

The results show that Venlafaxine combined with Sweet Dream oral liquid has a significant effect on middle school students with depression and mania. It can significantly improve the symptoms of depression and mania, alleviate the condition, and improve patients’ life quality. Therefore, this drug therapy can be considered as an effective treatment option for depression and mania in middle school students.

Introduction of talents in small and medium-sized cities under the background of government-school-enterprise cooperation Research-A case study of “100 universities visiting Shunde” in Guangdong province (No. pdjh2022b1094); Special Funds for the Cultivation of Guangdong College Students’ Scientific and Technological Innovation. “Climbing Program” Special Funds (No. pdjh2021a1005); Guangdong Province philosophy and Social Sciences “13th five year plan” 2020 discipline co construction project (No. GD20XJY54).