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Nonparametric Linkage Analysis Between Schizophrenia and Candidate Genes of Dopaminergic and Serotonergic Systems

Published online by Cambridge University Press:  07 November 2014

Alda M. Ambrósio ,
James L. Kennedy ,
Fabio Macciardi ,
Isabel Coelho ,
Maria J. Soares ,
Catarina R. Oliveira ,
Michele T. Pato  and
Carlos N. Pato
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Abstract

Background:

Alterations in dopaminergic and serotonergic systems have been implicated in the pathophysiology of schizophrenia for many years. This study was performed to assess the possible involvement of the dopamine receptor genes D2 (DRD2), D3, D4, serotonin receptor genes 1Dα, 1Dβ, and 2A in the etiology of schizophrenia.

Methods:

We examined 33 multiplex schizophrenic families from Portugal.

Results:

Linkage analysis performed by GENE-HUNTER showed nonsignificant linkage for these genes. A maximum nonparametric linkage score of 1.635 (P=.032) at DRD2 gene was observed, and this finding suggests DRD2 gene for further studies.

Conclusion:

the polymorphisms studied at dopamine receptor genes D3, D4, serotonin receptor genes 1Dα, 1Dβ, and 2A do not have a major effect in susceptibility to schizophrenia in a Portuguese population.

Type
Original Research
Information
CNS Spectrums , Volume 9 , Issue 4 , April 2004 , pp. 302 - 308
Copyright
Copyright © Cambridge University Press 2004

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