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Introduction and Clinical Presentations

Published online by Cambridge University Press:  07 November 2014

John P. O'Reardon
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Extract

Treatment-resistant depression (TRD) may be defined, both pragmatically and clinically, as the failure of an episode of major depression to respond fully to the adequate administration of a treatment that is known to be effective (Slide 1). It is important for the clinician, in terms of not inadvertently reinforcing stigma, to bear in mind, as the definition indicates, that it is the disease state or episode of depression that is treatment resistant, and not the patient, per se. The treatment that has failed must be a valid one and must also have been delivered effectively before one can conclude that this episode of major depression is resistant to any particular level of treatment.

Type
Expert Panel Supplement
Information
CNS Spectrums , Volume 14 , Issue S4: Pharmacologic and Therapeutic Strategies in Treatment-Resistant Depression , March 2009 , pp. 4 - 6
Copyright
Copyright © Cambridge University Press 2009

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References

1.O'Reardon, JP, Amsterdam, JD. Treatment-resistant depression: progress and limitations. Psychiatric Annals. 1998;28:633–640.CrossRefGoogle Scholar
2.O'Reardon, JP, Amsterdam, JD. Overview of treatment-resistant depression and its management. In: Amsterdam, JD, Hornig, M, Nierenberg, AA, eds. Treatment-resistant Mood Disorders. Cambridge; NY: Cambridge University Press; 2001:30–46.Google Scholar
3.O'Reardon, JP, Brunswick, DJ, Amsterdam, JD. Treatment-resistant depression in the age of serotonin: evolving strategies. Curr Opin Psychiatry. 2000;13(1):93–98.CrossRefGoogle Scholar
4.Greden, JF. The burden of disease for treatment-resistant depression. J Clin Psychiatry. 2001;62(suppl 16):26–31.Google ScholarPubMed
5.Sackeim, HA. The definition and meaning of treatment-resistant depression. J Clin Psychiatry. 2001;62 (suppl 16):10–17.Google Scholar
6.Khan, A, Schwartz, K. Study designs and outcomes in antidepressant clinical trials. Essential Psychopharmacol. 2005;6(4):221–226.Google ScholarPubMed
7.Prudic, J, Haskett, RF, Mulsant, B, et al. Resistance to antidepressant medications and short-term clinical response to ECT. [see comment] Am J Psychiatry. 1996;153(8):985–992.Google Scholar
8.George, MS, Rush, AJ, Marangell, LB, et al. A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression. Biol Psychiatry. 2005;58(5):364–373.Google Scholar
9.O'Reardon, JP, Solvason, H, Janicak, P, et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multi-site randomized controlled trial. Biol Psychiatry. 2007;62(11):1208–1216.Google Scholar
10.Souery, D, Amsterdam, J, de Montigny, C, et al. Treatment resistant depression: methodological overview and operational criteria. Eur Neuropsychopharmacol. 1999;9(1–2):83–91.CrossRefGoogle ScholarPubMed
11.Trivedi, MH, Rush, AJ, Wisniewski, SR, et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. [see comment] Am J Psychiatry. 2006;163(1):28–40.CrossRefGoogle ScholarPubMed
12.Borkovec, TD, Ruscio, AM. Psychotherapy for generalized anxiety disorder. J Clin Psychiatry. 2001;62(suppl 11):37–42; discussion 43–45.Google ScholarPubMed
13.Pollack, MH. Comorbid anxiety and depression. J Clin Psychiatry. 2005;66(suppl 8):22–29.Google Scholar
14.Petersen, T, Hughes, M, Papakostas, GI, et al. Treatment-resistant depression and Axis II comorbidity. Psychother Psychosom. 2002;71(5):269–274.CrossRefGoogle ScholarPubMed
15.Thase, ME, Friedman, ES, Howland, RH. Management of treatment-resistant depression: psychotherapeutic perspectives. J Clin Psychiatry. 2001;62(suppl 18)8:18–24.Google Scholar
16.Yates, WR, Mitchell, J, Rush, AJ, et al. Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR*D. Gen Hosp Psychiatry. 2004;26(6):421–429.CrossRefGoogle ScholarPubMed
17.Keller, MB, Klerman, GL, Lavori, PW, et al. Long-term outcome of episodes of major depression. Clinical and public health significance. JAMA. 1984;252(6):788–792.Google Scholar
18.Solomon, DA, Keller, MB, Leon, AC, et al. Recovery from major depression. A 10-year prospective follow-up across multiple episodes. Arch Gen Psychiatry. 1997;54(11):1001–1006.Google Scholar
19.Rothschild, AJ. Challenges in the treatment of depression with psychotic features. Biol Psychiatry. 2003;53(8):680–690.CrossRefGoogle ScholarPubMed
20.Petrides, G, Fink, M, Husain, MM, et al. ECT remission rates in psychotic versus nonpsychotic depressed patients: a report from CORE. J ECT. 2001;17(4):244–253.CrossRefGoogle Scholar
21.Ghaemi, SN, Boiman, EE, Goodwin, FK. Diagnosing bipolar disorder and the effect of antidepressants: a naturalistic study. J Clin Psychiatry. 2000;61(10):804–808;quiz 809.Google Scholar
22.Miller, CJ, Klugman, J, Berv, DA, Rosenquist, KJ, Ghaemi, SN. Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorder. J Affect Disord. 2004;81(2):167–171.Google Scholar
23.Rush, AJ, Trivedi, MH, Wisniewski, SR, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163(11):1905–1917.CrossRefGoogle ScholarPubMed