The treatment of depression is mainly to eliminate and improve the symptoms of patients. At present, there are a variety of clinical antidepressants for the treatment of depression, however, there are still some patients with no significant therapeutic effect. When the effect of antidepressants alone is not satisfactory for patients with refractory depression, synergistic therapy can be considered, which is atypical antipsychotics being used as synergists in combination with antidepressants. Based on this background, this project conducted relevant research on patients with depression as research samples.

The control group was given paroxetine tablets at a dose of 20 mg/d as prescribed by the doctor, and the dose was increased to 30 mg/d after 1 week. On the basis of the control group, the study group was given atypical antipsychotic olanzapine tablets at a dose of 5 mg/d as prescribed by the doctor. The score of depression degree was represented by the Hamilton Rating Scale for Depression (HAMD) score. The score of life quality was referred to the brief form of Health survey (SF-36 scale). SPSS20.0 software was used for statistical processing of various indicators of the 2 groups.

After treatment, HAMD scores decreased and SF-36 scores increased in the study group and control group, and HAMD scores and SF-36 scores in the study group were significantly better than those in the control group after treatment (P < 0.05).

Antidepressant drugs (paroxetine tablets) combined with atypical antipsychotic drugs (olanzapine tablets) are effective in the treatment of depression, and can effectively improve the quality of life of patients.

2019 Teaching Reform Research Project of Chongqing Municipal Education Commission (No. 193144); Chongqing Educational Science Planning Project (No. 2019-GX-352).