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Brain-derived neurotrophic factor among patients with alcoholism

Published online by Cambridge University Press:  19 May 2020

Candelaria Martín-González Open the ORCID record for Candelaria Martín-González [Opens in a new window] ,
Lucía Romero-Acevedo ,
Camino María Fernández-Rodríguez ,
Lilian Medina-Vega ,
Alen García-Rodríguez ,
Paula Ortega-Toledo ,
Lourdes González-Navarrete ,
Víctor Eugenio Vera-Delgado  and
Emilio González-Reimers
Candelaria Martín-González*
Affiliation:
Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Canary Islands, Spain
Lucía Romero-Acevedo
Affiliation:
Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Canary Islands, Spain
Camino María Fernández-Rodríguez
Affiliation:
Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Canary Islands, Spain
Lilian Medina-Vega
Affiliation:
Laboratorio Central, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Canary Islands, Spain
Alen García-Rodríguez
Affiliation:
Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Canary Islands, Spain
Paula Ortega-Toledo
Affiliation:
Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Canary Islands, Spain
Lourdes González-Navarrete
Affiliation:
Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Canary Islands, Spain
Víctor Eugenio Vera-Delgado
Affiliation:
Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Canary Islands, Spain
Emilio González-Reimers
Affiliation:
Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Canary Islands, Spain
*
*Candelaria Martín-González, Email: candemartin1983@gmail.com
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Abstract

Background

Brain-derived neurotrophic factor (BDNF) is involved in neurogenesis and in the protection against oxidative damage and neuronal apoptosis. After exercise, there is an increased expression of this myokine, especially in skeletal muscle and brain. Low BDNF levels have been described in neurodegenerative diseases. Alcoholics show both muscle atrophy and brain atrophy. Thus, this study was performed in order to analyze serum BDNF levels among alcoholics and their associations with brain atrophy and muscle strength.

Methods

Serum BDNF values were determined to 82 male alcoholics and 27 age-matched controls, and compared with handgrip strength, with the presence of brain atrophy, assessed by computed tomography, and with the intensity of alcoholism and liver function derangement.

Results

BDNF levels and handgrip strength were significantly lower among patients. Handgrip strength was correlated with BDNF values, both in the whole population and in alcoholics, especially in patients over 59 years of age. BDNF was poorly related to liver dysfunction but showed no relationship with brain atrophy or age.

Conclusion

Chronic alcoholics show decreased BDNF serum levels that are related to muscle function impairment rather than to age, brain atrophy, liver dysfunction, or the amount of ethanol consumed.

Keywords

Brain-derived neurotrophic factorBDNFalcoholismalcoholic myopathybrain atrophymyokines
Type
Original Research
Information
CNS Spectrums , Volume 26 , Issue 4 , August 2021 , pp. 400 - 405
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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