Bipolar depression usually manifests as a fluctuating mood in patients, with symptoms similar to severe depression yet easily overlooked. The symptoms of bipolar depression among college students are not very obvious. The study used a mixed teaching model to intervene and assist in treatment for students, and combined with oral therapy to compare curing effects.

Select 60 students of art education major with bipolar depression from a college and randomly divide them into two groups with 30 cases in each group. Secondly, the control group was treated with fluoxetine, while the observation group was treated with fluoxetine combined with oral therapy. Both groups were assisted by a blended teaching approach. Finally, the thyroid hormone levels before and after treatment were compared between the two groups, using SPSS 23.0 for statistical analysis and t-test.

The statistical differences in the levels of Triiodothyronine (T3), Thyroxine (T4), and Thyroid Stimulating Hormone (TSH) in the control group before treatment were not significant (P>0.05). After treatment, the levels of T3, T4, and TSH in the control group decreased and the differences were statistically significant (P<0.05). The thyroid hormone levels in the observation group after treatment were significantly lower than those in the control group, with a statistically significant difference (P<0.001).

Patients with bipolar depression experienced abnormal thyroid hormone levels before treatment, and their hormone levels were effectively relieved after treatment, indicating the feasibility of the proposed treatment.