Anxiety is a painful emotional experience disproportionate to the situation, manifested as anxiety without a definite objective object and specific conceptual content. With the severe employment situation, more and more college students have become self-employed. Under the enormous pressure and risks of entrepreneurship, some college students have developed anxiety.

The Cochrane Library search was conducted on past research on entrepreneurial anxiety, using keywords such as anxiety and psychotherapy. Forty college students who started their businesses were randomly divided into two groups. One group received innovation and entrepreneurship education, while the other was the control group. Before and after the innovation and entrepreneurship education, these students were tested with electromyographic indicators and a self-rating anxiety scale.

Innovation and entrepreneurship education have a significant effect on alleviating entrepreneurial risk anxiety among college students. There is a significant difference in the post-test electromyographic indicators compared to the pre-test (t=-4.46, P<0.05), and there is a significant difference in the scores of the post-test anxiety self-assessment scale compared to the pre-test (t=-4.23, P<0.05).

The anxiety of college students is one of the critical factors affecting their entrepreneurship, and it is urgent to adopt effective methods and timely intervention and treatment in a retrograde manner. Innovation and entrepreneurship education in vocational colleges can effectively alleviate the anxiety of college students, which is of great significance for their mental health and career development.