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Availability of dopamine transporters and auditory P300 abnormalities in adults with attention-deficit hyperactivity disorder: preliminary results

Published online by Cambridge University Press:  29 August 2017

Ching-Lin Chu
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
I Hui Lee
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
Mei Hung Chi*
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Kao Chin Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
Po See Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
Wei Jen Yao
Affiliation:
Department of Nuclear Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Nan Tsing Chiu
Affiliation:
Department of Nuclear Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Yen Kuang Yang
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
*
*Address correspondence and reprint requests to: Mei Hung Chi, Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, North District, Tainan 704, Taiwan. (Email: leomerechi@gmail.com)

Abstract

Objective

Previous studies have indicated that there is dopamine transporter (DAT) dysregulation and P300 abnormality in adults with attention-deficit hyperactivity disorder (ADHD); however, the correlations among the three have not been fully explored.

Methods

A total of 11 adults (9 males and 2 females) with ADHD and 11 age-, sex-, and education-level-matched controls were recruited. We explored differences in DAT availability using single-photon emission computed tomography and P300 wave of event-related potentials between the two groups. The correlation between DAT availability and P300 performance was also examined.

Results

DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the ADHD group. Adults with ADHD had lower auditory P300 amplitudes at the Pz and Cz sites, as well as longer Fz latency than controls. DAT availability was negatively correlated to P300 latency at Pz and Fz.

Conclusions

Adults with ADHD had both abnormal DAT availability and P300 amplitude, suggesting that ADHD is linked to dysfunction of the central dopaminergic system and poor cognitive processes related to response selection and execution.

Type
Original Research
Copyright
© Cambridge University Press 2017 

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References

1. Spencer, TJ, Biederman, J, Madras, BK, et al. In vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporter. Biol Psychiatry. 2005; 57: 12931300.Google Scholar
2. Bowton, E, Saunders, C, Erreger, K, et al. Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. J Neurosci. 2010; 30: 60486057. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881830/pdf/nihms200116.pdf. Accessed January 16, 2017.Google Scholar
3. Solanto, MV. Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research. Behav Brain Res. 2002; 130: 6571.Google Scholar
4. Fusar-Poli, P, Rubia, K, Rossi, G, Sartori, G, Balottin, U. Striatal dopamine transporter alterations in ADHD: pathophysiology or adaptation to psychostimulants? A meta-analysis. Am J Psychiatry. 2012; 169: 264272. http://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2011.11060940. Accessed January 16, 2017.Google Scholar
5. Volkow, ND, Wang, GJ, Newcorn, J, et al. Brain dopamine transporter levels in treatment and drug naïve adults with ADHD. NeuroImage. 2007; 34: 11821190.Google Scholar
6. Steve, L. An Introduction to the Event-Related Potential Technique. Cambridge: MIT Press; 2005.Google Scholar
7. Polich, J. Updating P300: an integrative theory of P3a and P3b. Clin Neurophysiol. 2007; 118(10): 21282148. Epub ahead of print Jun 18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715154/. Accessed January 16, 2017.Google Scholar
8. Szuromi, B, Czobor, P, Komlósi, S, Bitter, I. P300 deficits in adults with attention deficit hyperactivity disorder: a meta-analysis. Psychol Med. 2011; 41(7): 15291538. Epub ahead of print Oct 20, 2010.Google Scholar
9. Barry, RJ, Clarke, AR, Johnstone, SJ. A review of electrophysiology in attention-deficit/hyperactivity disorder, I: qualitative and quantitative electroencephalography. Clin Neurophysiol. 2003; 114(2): 171183.Google Scholar
10. Barry, RJ, Johnstone, SJ, Clarke, AR. A review of electrophysiology in attention-deficit/hyperactivity disorder, II: event-related potentials. Clin Neurophysiol. 2003; 114(2): 184198.Google Scholar
11. Chen, KC, Lee, IH, Yang, YK, et al. P300 waveform and dopamine transporter availability: a controlled EEG and SPECT study in medication-naive patients with schizophrenia and a meta-analysis. Psychol Med. 2014; 44(10): 21512162. Epub ahead of print Nov 15, 2013.Google Scholar
12. Chen, KC, Yang, YK, Howes, O, et al. Striatal dopamine transporter availability in drug-naive patients with schizophrenia: a case-control SPECT study with [99mTc]-TRODAT-1 and a meta-analysis. Schizophr Bull. 2013; 39(2): 378386. Epub ahead of print Dec 8, 2011. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576153/. Accessed January 16, 2017.Google Scholar
13. Chen, PS, Yeh, TL, Lee, IH, et al. Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers: a SPECT study. NeuroImage. 2011; 56(3): 15261530. Epub ahead of print Mar 1.Google Scholar
14. Hwang, WJ, Yao, WJ, Wey, SP, Ting, G. Reproducibility of 99mTc-TRODAT-1 SPECT measurement of dopamine transporters in Parkinson’s disease. J Nucl Med. 2004; 45(2): 207213. http://jnm.snmjournals.org/content/45/2/207.long. Accessed January 16, 2017.Google Scholar
15. Picton, TW, Bentin, S, Berg, P, et al. Guidelines for using human event-related potentials to study cognition: recording standards and publication criteria. Psychophysiology. 2000; 37(2): 127152.Google Scholar
16. Wechsler, D. Wechsler Adult Intelligence Scale–Revised Manual anglicized, ed London: Psychological Corporation; 1986.Google Scholar
17. Kessler, RC, Ustun, TB. The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI). Int J Methods Psychiatr Res. 2004; 13(2): 93121.Google Scholar
18. Kessler, RC, Adler, L, Ames, M, et al. The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population. Psychol Med. 2005; 35(2): 245256.Google Scholar
19. Yeh, CB, Gau, SS, Kessler, RC, Wu, YY. Psychometric properties of the Chinese version of the adult ADHD Self-Report Scale. Int J Methods Psychiatr Res. 2008; 17(1): 4554.Google Scholar
20. Cohen, J. Statistical Power Analysis for the Behavioral Sciences, 2nd ed. Milton Park, NJ: Lawrence Erlbaum Associates; 1988.Google Scholar
21. Hesse, S, Ballaschke, O, Barthel, H, Sabri, O. Dopamine transporter imaging in adult patients with attention-deficit/hyperactivity disorder. Psychiatry Res. 2009; 171(2): 120128. Epub ahead of print Jan 26.Google Scholar
22. Volkow, ND, Wang, GJ, Kollins, SH, et al. Evaluating dopamine reward pathway in ADHD: clinical implications. JAMA. 2009; 302(10): 10841091. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958516/Accessed January 16, 2017.Google Scholar
23. Wang, GJ, Volkow, N, Wigal, T, et al. Chronic treatment with methylphenidate increases dopamine transporter density in patients with attention deficit hyperactive disorder. J Nucl Med. 2009; 50(Suppl. 2): 1283.Google Scholar
24. Ford, JM, Sullivan, EV, Marsh, L, White, PM, Lim, KO, Pfefferbaum, A. The relationship between P300 amplitude and regional gray matter volumes depends upon the attentional system engaged. Electroencephalogr Clin Neurophysiol. 1994; 90(3): 214228.Google Scholar
25. Azizian, A, Polich, J. Evidence for attentional gradient in the serial position memory curve from event-related potentials. J Cogn Neurosci. 2007; 19(12): 20712081. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748728/. Accessed January 16, 2017.Google Scholar
26. Gershon, J, Gershon, J. A meta-analytic review of gender differences in ADHD. J Atten Disord. 2002; 5(3): 143154.Google Scholar
27. Roessner, V, Sagvolden, T, Dasbanerjee, T, et al. Methylphenidate normalizes elevated dopamine transporter densities in an animal model of the attention-deficit/hyperactivity disorder combined type, but not to the same extent in one of the attention-deficit/hyperactivity disorder inattentive type. Neuroscience. 2010; 167(4): 11831191. Epub ahead of print Mar 6.Google Scholar
28. Hannestad, J, Gallezot, JD, Planeta-Wilson, B, et al. Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo. Biol Psychiatry. 2010; 68(9): 854860. Epub ahead of print Aug 5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742016/. Accessed January 16, 2017.Google Scholar
29. Wang, GJ, Volkow, ND, Wigal, T, et al. Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder. PLoS One. 2013; 8(5): e63023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655054/. Accessed January 16, 2017.Google Scholar