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Usefulness of ischemia-modified albumin for assessment of the effects of small ventricular septal defects on the pulmonary vascular bed

Part of: Ventricular Septal Defect (VSD) Echocardiography

Published online by Cambridge University Press:  22 March 2021

Pinar Dervisoglu Open the ORCID record for Pinar Dervisoglu [Opens in a new window]  and
Taliha Oner Open the ORCID record for Taliha Oner [Opens in a new window]
Pinar Dervisoglu*
Affiliation:
Sakarya University, Faculty of Medicine, Department of Pediatric Cardiology, Sakarya, Turkey
Taliha Oner
Affiliation:
University of Health Sciences, Dr Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Pediatric Cardiology, Istanbul, Turkey
*
Author for correspondence: Dr P. Dervisoglu, MD, Sakarya University, Medical Faculty Department of Pediatric Cardiology, Adnan Menderes Street, Sakarya 54100, Turkey. Tel: +090 505 9231960; Fax: +90 264 2745086. E-mail: pdervisoglu@hotmail.com
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Abstract

Background:

Pulmonary vascular damage may be associated with oxidative stress in congenital heart diseases. We investigated whether small ventricular septal defects have an effect on the pulmonary bed.

Methods:

This prospective cohort study included 100 patients with small ventricular septal defects and 75 healthy controls. Ischemia-modified albumin, high-sensitivity C-reactive protein, and various cardiovascular parameters were assessed in both groups.

Results:

The mean ischemia-modified albumin level was significantly higher in patients with small ventricular septal defects (0.62 ± 0.17 absorbance units) than in the control group (0.51 ± 0.09 absorbance units; p < 0.001). The mean high-sensitivity C-reactive protein level was significantly higher in the ventricular septal defects group (3.72 ± 1.57) than in the control group (2.45 ± 0.89; p < 0.001). The ischemia-modified albumin levels in patients with left ventricular internal diameter end diastole and end sistole and main pulmonary artery z-scores ≥ 2 were significantly higher than patients whose z-scores were <2. The ischemia-modified albumin and high-sensitivity C-reactive protein levels were positively correlated in the small ventricular septal defects group (rho = 0.742, p < 0.001). Receiver operating characteristic analyses showed that at the optimal cut-off value of ischemia-modified albumin for the prediction of pulmonary involvement was 0.55 absorbance units with a sensitivity of 60%, specificity of 62% (area under the curve = 0.690, p < 0.001).

Conclusions:

We demonstrated the presence of oxidative stress and higher ischemia-modified albumin levels in small ventricular septal defects, suggesting that ischemia-modified albumin might be a useful biomarker for evaluating the effects of small ventricular septal defects on the pulmonary bed.

Keywords

Childhoodischemia-modified albuminpulmonary vasculary bedventricular septal defect
Type
Original Article
Information
Cardiology in the Young , Volume 31 , Issue 7 , July 2021 , pp. 1207 - 1212
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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