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Trisomy 21, transposition of the great arteries and abnormal myelopoiesis

Part of: Surgery

Published online by Cambridge University Press:  21 June 2021

Chandan Mishra ,
Lamk Kadiyani ,
Sivasubramanian Ramakrishnan  and
Tushar Sehgal Open the ORCID record for Tushar Sehgal [Opens in a new window]
Chandan Mishra
Affiliation:
Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India
Lamk Kadiyani
Affiliation:
Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
Sivasubramanian Ramakrishnan
Affiliation:
Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
Tushar Sehgal*
Affiliation:
Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India
*
Author for correspondence: Dr Tushar Sehgal, MD (Pathology) DM (Hematopathology), Assistant Professor, Department of Laboratory Medicine, Second Floor, Teaching Block, All India Institute of Medical Sciences, New Delhi, India. Tel: +918558843932. E-mail: Doctusharsehgal@yahoo.co.in
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Abstract

Down syndrome is a well-recognised genetic condition associated with several comorbidities. Although CHD is common in Down syndrome, transposition of the great arteries is exceptionally rare. We describe a neonate with Down syndrome who presented with transient abnormal myelopoiesis and transposition of the great arteries. Down syndrome may accelerate pulmonary hypertension in transposition of the great arteries and is associated with poor outcomes.

Keywords

Down syndrometransposition of great arteriestransient abnormal myelopoiesis pulmonary hypertension
Type
Brief Report
Information
Cardiology in the Young , Volume 32 , Issue 1 , January 2022 , pp. 142 - 143
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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