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To go left or right? Driving towards the best direction in paediatric pacing

Published online by Cambridge University Press:  08 June 2022

Massimo Stefano Silvetti Open the ORCID record for Massimo Stefano Silvetti [Opens in a new window] ,
Luigina Porco ,
Ilaria Tamburri ,
Marta Campisi ,
Fabrizio Gimigliano ,
Fabio Anselmo Saputo ,
Chiara Mizzon ,
Corrado Di Mambro Open the ORCID record for Corrado Di Mambro [Opens in a new window] ,
Sonia Albanese  and
Lucilla Ravà
...Show all authors
Massimo Stefano Silvetti*
Affiliation:
Paediatric Cardiology and Cardiac Arrhythmias Unit, Bambino Gesù Children’s Hospital IRCCS, Piazza Sant’Onofrio 4, Rome 00165, Italy
Luigina Porco
Affiliation:
Paediatric Cardiology and Cardiac Arrhythmias Unit, Bambino Gesù Children’s Hospital IRCCS, Piazza Sant’Onofrio 4, Rome 00165, Italy
Ilaria Tamburri
Affiliation:
Paediatric Cardiology and Cardiac Arrhythmias Unit, Bambino Gesù Children’s Hospital IRCCS, Piazza Sant’Onofrio 4, Rome 00165, Italy
Marta Campisi
Affiliation:
Paediatric Cardiology and Cardiac Arrhythmias Unit, Bambino Gesù Children’s Hospital IRCCS, Piazza Sant’Onofrio 4, Rome 00165, Italy
Fabrizio Gimigliano
Affiliation:
Paediatric Cardiology and Cardiac Arrhythmias Unit, Bambino Gesù Children’s Hospital IRCCS, Piazza Sant’Onofrio 4, Rome 00165, Italy
Fabio Anselmo Saputo
Affiliation:
Paediatric Cardiology and Cardiac Arrhythmias Unit, Bambino Gesù Children’s Hospital IRCCS, Piazza Sant’Onofrio 4, Rome 00165, Italy
Chiara Mizzon
Affiliation:
Paediatric Cardiology and Cardiac Arrhythmias Unit, Bambino Gesù Children’s Hospital IRCCS, Piazza Sant’Onofrio 4, Rome 00165, Italy
Corrado Di Mambro
Affiliation:
Paediatric Cardiology and Cardiac Arrhythmias Unit, Bambino Gesù Children’s Hospital IRCCS, Piazza Sant’Onofrio 4, Rome 00165, Italy
Sonia Albanese
Affiliation:
Cardiac Surgery Unit, Bambino Gesù Children’s Hospital IRCCS, Piazza Sant’Onofrio 4, Rome 00165, Italy
Lucilla Ravà
Affiliation:
Epidemiology Institute, Bambino Gesù Children’s Hospital IRCCS, Piazza Sant’Onofrio 4, Rome 00165, Italy
Fabrizio Drago
Affiliation:
Paediatric Cardiology and Cardiac Arrhythmias Unit, Bambino Gesù Children’s Hospital IRCCS, Piazza Sant’Onofrio 4, Rome 00165, Italy
*
Author for correspondence: Massimo Stefano Silvetti, MD, Paediatric Cardiology and Cardiac Arrhythmias Unit, Department of Paediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital and Research Institute, Piazza Sant’Onofrio 4, Rome 00165, Italy. Tel. +39 06 68593354; Fax +39 06 68594841. E-mail: mstefano.silvetti@opbg.net
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Abstract

Background:

Permanent pacing in children with isolated congenital complete atrioventricular block may cause left ventricular dysfunction. To prevent it, alternative pacing sites have been proposed: left ventricular epicardial or selective right ventricular endocardial pacing.

Aims:

To compare the functional outcome (left ventricular systolic function and synchrony) in paediatric patients with congenital complete atrioventricular block and left ventricular apical epicardial or right ventricular transvenous mid-septal pacing.

Methods:

Retrospective study. Epicardial leads were implanted by standard surgical technique, transvenous leads by 3D electroanatomic mapping systems. 3D mapping acquired 3D right ventricular local pacing map and defined the narrowest paced QRS site. 3D mapping guided screw-in bipolar leads on that ventricular site. Electrocardiogram (ECG) (QRS duration) and echocardiographic data (synchrony: interventricular mechanical delay, septal to posterior wall motion delay, systolic dyssynchrony index; contractility: global longitudinal strain, ejection fraction) were recorded. Data are reported as median [interquartile ranges]. p < 0.05 was significant.

Results:

There were 19 transvenous systems (age 8.8 [6–14] years; right ventricular mid-septum) and 17 epicardial systems (0.04 [0.001–0.6] years; left ventricular apex). Post-implantation QRS significantly widened either in endocardial or in epicardial patients. Most patients reached 4-year follow-up. One-year and 4-year ejection fraction and global longitudinal strain were mostly within normal limits and did not show significant differences between the two groups and between the same endocardial/epicardial group. Synchrony parameters were within normal limits in the two groups.

Conclusions:

Left ventricular apical epicardial pacing and 3D mapping-guided right ventricular mid-septal pacing preserved left ventricular contractility and synchrony in children and adolescents with congenital complete atrioventricular block at short-/mid-term follow-up, without relevant significant differences between the two groups.

Keywords

ChildrenCardiac pacingAlternative pacing sitesCongenital atrioventricular blockHeart failureElectroanatomic mapping systems
Type
Original Article
Information
Cardiology in the Young , Volume 33 , Issue 5 , May 2023 , pp. 760 - 765
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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