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Pregnancy and early post-natal outcomes of fetuses with functionally univentricular heart in a low-and-middle-income country

Published online by Cambridge University Press:  22 September 2020

Balu Vaidyanathan Open the ORCID record for Balu Vaidyanathan [Opens in a new window] ,
Aparna Vijayaraghavan Open the ORCID record for Aparna Vijayaraghavan [Opens in a new window] ,
Stephy Thomas  and
Abish Sudhakar
Balu Vaidyanathan*
Affiliation:
The Fetal Cardiology Division, Department of Paediatric Cardiology, Amrita Institute of Medical Sciences, AIMS Ponekkara PO, Kochi, Kerala, India682 041
Aparna Vijayaraghavan
Affiliation:
The Fetal Cardiology Division, Department of Paediatric Cardiology, Amrita Institute of Medical Sciences, AIMS Ponekkara PO, Kochi, Kerala, India682 041
Stephy Thomas
Affiliation:
The Fetal Cardiology Division, Department of Paediatric Cardiology, Amrita Institute of Medical Sciences, AIMS Ponekkara PO, Kochi, Kerala, India682 041
Abish Sudhakar
Affiliation:
The Fetal Cardiology Division, Department of Paediatric Cardiology, Amrita Institute of Medical Sciences, AIMS Ponekkara PO, Kochi, Kerala, India682 041
*
Author for correspondence: Dr Balu Vaidyanathan, Clinical Professor, Paediatric Cardiology Head, Fetal Cardiology division, Amrita Institute of Medical Sciences, Kochi, Kerala, India, 682 041. Tel: +91 484 285 3570; Fax: +91 484 280 2020; Mobile: +91 94958 20684. E-mail: baluvaidyanathan@gmail.com
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Abstract

Background:

Care of children with functionally univentricular hearts is resource-intensive.

Objectives:

To analyse pregnancy and early post-natal outcomes of fetuses with functionally univentricular hearts in the setting of a low–middle-income country.

Methods:

A retrospective study was conducted during the period of January 2008–October 2019. Study variables analysed included gestational age at diagnosis, maternal and fetal comorbidities and cardiac diagnosis including morphologic type of single ventricle. Outcomes analysed included pregnancy outcomes, type of post-natal care and survival status on the last follow-up.

Results:

A total of 504 fetuses were included. Mean maternal age was 27.5 ± 4.8 years and mean gestational age at diagnosis was 25.6 ± 5.7 weeks. Pregnancy outcomes included non-continued pregnancies (54%), live births (42.7%) and loss to follow-up (3.3%). Gestational age at diagnosis was the only factor that impacted pregnancy outcomes (non-continued pregnancies 22.5 ± 3.5 vs. live births 29.7 ± 5.7 weeks; p < 0.001). Of the 215 live births, intention-to-treat was reported in 119 (55.3%) cases; of these 103 (86.6%) underwent cardiac procedures. Seventy-nine patients (36.7%) opted for comfort care. On follow-up (median 10 (1–120) months), 106 patients (21%) were alive. Parental choice of intention-to-.treat or comfort care was the only factor that impacted survival on follow-up.

Conclusions:

Prenatal diagnosis of functionally univentricular hearts was associated with overall low survival status on follow-up due to parental decisions on not to continue pregnancy or non-intention-to-treat after birth. Early detection of these complex defects by improved prenatal screening can enhance parental options and reduce resource impact in low-and-middle-income countries.

Keywords

Functionally univentricular heartlow-and-middle-income countryoutcomes
Type
Original Article
Information
Cardiology in the Young , Volume 30 , Issue 12 , December 2020 , pp. 1844 - 1850
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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