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Plasma adiponectin levels and relations with cytokines in children with acute rheumatic fever

Published online by Cambridge University Press:  16 June 2014

Huriye Ozgen ,
Birsen Ucar ,
Ali Yildirim ,
Omer Colak ,
Cengiz Bal  and
Zubeyir Kilic
Huriye Ozgen
Affiliation:
Medical Faculty, Department of Pediatric Cardiology, Eskisehir Osmangazi University, Eskisehir, Turkey
Birsen Ucar
Affiliation:
Medical Faculty, Department of Pediatric Cardiology, Eskisehir Osmangazi University, Eskisehir, Turkey
Ali Yildirim*
Affiliation:
Medical Faculty, Department of Pediatric Cardiology, Eskisehir Osmangazi University, Eskisehir, Turkey
Omer Colak
Affiliation:
Medical Faculty, Department of Biochemistry, Eskisehir Osmangazi University, Eskisehir, Turkey
Cengiz Bal
Affiliation:
Medical Faculty, Department of Biostatistics, Eskisehir Osmangazi University, Eskisehir, Turkey
Zubeyir Kilic
Affiliation:
Medical Faculty, Department of Pediatric Cardiology, Eskisehir Osmangazi University, Eskisehir, Turkey
*
Correspondence to: Dr A. Yildirim, Eskisehir Osmangazi Üniversitesi, Tıp Fakultesi, Pediatrik Kardiyoloji Bilim Dalı, 26480, Eskisehir, Turkey. Tel: +9 0 530 882 2319 (GSM); Fax: +9 0 222 239 2979/7440; E-mail: yldrmaly@gmail.com
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Abstract

Aim: We aimed to investigate the role of adiponectin in acute rheumatic fever by evaluating correlations with cytokines and acute-phase reactants. Methods: Patients were divided into three groups by clinical findings. Group 1 included 8 patients with only chorea, Group 2 included 13 patients with arthritis and carditis, and Group 3 included 12 patients with only carditis. A total of 54 age- and gender-matched children were enrolled in the control group. Blood samples were drawn for analysing acute-phase reactants, adiponectin, tumour necrosis factor-α, interleukin-6, and interleukin-8 levels at baseline on Days 2, 5, 10, and 15, and at 8 weeks. Results: There was no statistically significant difference between baseline age, gender, body mass index, serum triglyceride, total cholesterol, and low-density lipoprotein levels of the study and control groups (p>0.05). No correlation was found between baseline plasma adiponectin levels, age, body mass index, follicle-stimulating hormone, luteinising hormone, oestradiol, total testosterone, and blood lipid levels of the study and control groups (p>0.05). We found that adiponectin and interleukin-6 levels increased, tumour necrosis factor-α levels decreased, and interleukin-8 levels remained unchanged in acute rheumatic fever, which is an inflammatory disease. Moreover, adiponectin level was higher and tumour necrosis factor-α level was lower in the improvement period in comparison with the acute period, particularly in the carditis group. Conclusion: It was considered that, increasing throughout the treatment period, adiponectin may have anti-inflammatory effects in acute rheumatic fever. In addition, adiponectin levels are associated with a decline in inflammatory mediators in rheumatic fever.

Keywords

Adiponectincytokinesacute rheumatic fever
Type
Original Articles
Information
Cardiology in the Young , Volume 25 , Issue 5 , June 2015 , pp. 879 - 892
Copyright
© Cambridge University Press 2014 

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