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Physiological changes in blood pressure impact peripheral endothelial function during adolescence

Published online by Cambridge University Press:  16 June 2014

Livia Deda ,
Etienne B. Sochett  and
Farid H. Mahmud
Livia Deda
Affiliation:
Department of Endocrinology, Hospital for Sick Children, University of Toronto, Ontario, Canada
Etienne B. Sochett
Affiliation:
Department of Endocrinology, Hospital for Sick Children, University of Toronto, Ontario, Canada Faculty of Medicine, Department of Pediatrics, University of Toronto, Ontario, Canada
Farid H. Mahmud*
Affiliation:
Department of Endocrinology, Hospital for Sick Children, University of Toronto, Ontario, Canada Faculty of Medicine, Department of Pediatrics, University of Toronto, Ontario, Canada
*
Correspondence to: Dr F. H. Mahmud MD, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1×8. Tel: 416-813-6218; Fax: 416-813-6304; E-mail: farid.mahmud@sickkids.ca
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Abstract

Reactive hyperemia index is a measure of endothelial function used to assess subclinical atherosclerosis. When evaluated in healthy adolescents, significant changes in endothelial function were correlated with advancing age, pubertal status, and blood pressure. Blood pressure was the principal contributor to reactive hyperemia index variability independent of age, lipid profile, body mass index, and/or pubertal status. Interpretation of this peripheral vascular marker should include age and maturational changes in paediatric patients.

Keywords

Diabetesadolescentsendothelial functionreactive hyperemia index
Type
Brief Reports
Information
Cardiology in the Young , Volume 25 , Issue 4 , April 2015 , pp. 777 - 779
Copyright
© Cambridge University Press 2014 

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References

1. Urbina, EM, Williams, RV, Alpert, BS, et al. Noninvasive assessment of subclinical atherosclerosis in children and adolescents: recommendations for standard assessment for clinical research: a scientific statement from the American Heart Association. Hypertension 2009; 54: 919–950.CrossRefGoogle ScholarPubMed
2. Lee, CR, Bass, A, Ellis, K, et al. Relation between digital peripheral arterial tonometry and brachial artery ultrasound measures of vascular function in patients with coronary artery disease and in healthy volunteers. Am J Cardiol 2012; 109: 651–657.CrossRefGoogle ScholarPubMed
3. Bhangoo, A, Sinha, S, Rosenbaum, M, Shelov, S, Ten, S. Endothelial function as measured by peripheral arterial tonometry increases during pubertal advancement. Horm Res Paediatr 2011; 76: 226–233.CrossRefGoogle ScholarPubMed
4. Radtke, T, Khattab, K, Eser, P, Kriemler, S, Saner, H, Wilhelm, M. Puberty and microvascular function in healthy children and adolescents. J Pediatr 2012; 161: 887–891.CrossRefGoogle ScholarPubMed
5. Bonetti, PO, Pumper, GM, Higano, ST, Holmes, DR Jr, Kuvin, JT, Lerman, A. Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol 2004; 44: 2137–2141.CrossRefGoogle ScholarPubMed
6. Haller, MJ, Stein, J, Shuster, J, et al. Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes. Pediatr Diabetes 2007; 8: 193–198.CrossRefGoogle ScholarPubMed
7. Nohria, A, Gerhard-Herman, M, Creager, MA, Hurley, S, Mitra, D, Ganz, P. Role of nitric oxide in the regulation of digital pulse volume amplitude in humans. J Appl Physiol 2006; 101: 545–548.CrossRefGoogle ScholarPubMed
8. Hamburg, NM, Keyes, MJ, Larson, MG, et al. Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study. Circulation 2008; 117: 2467–2474.CrossRefGoogle ScholarPubMed
9. Yang, WI, Park, S, Youn, JC, et al. Augmentation index association with reactive hyperemia as assessed by peripheral arterial tonometry in hypertension. Am J Hypertens 2011; 24: 1234–1238.CrossRefGoogle ScholarPubMed