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Ketorolac-associated renal morbidity: risk factors in cardiac surgical infants

Published online by Cambridge University Press:  22 October 2012

Brady S. Moffett  and
Antonio Cabrera
Brady S. Moffett*
Affiliation:
Department of Pharmacy, Texas Children's Hospital, Houston, Texas, United States of America
Antonio Cabrera
Affiliation:
Department of Pediatrics, Section of Pediatric Cardiology, Baylor College of Medicine, Houston, Texas, United States of America
*
Correspondence to: Dr B. S. Moffett, PharmD, MPH, Department of Pharmacy, Texas Children's Hospital, 6621 Fannin Street, Suite WB 1120, Houston, Texas 77030, United States of America. Tel: +1 832 824 6087; Fax: +1 832 825 5261; E-mail: bsmoffet@texaschildrens.org
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Abstract

We aimed to identify the risk factors for acute kidney injury in infants who have received ketorolac after a cardiac surgical procedure by identifying patients with a ≥50% increase in serum creatinine from baseline and matching them by age with three controls that had <50% increase in serum creatinine. Significant differences in primary surgical procedure, baseline serum creatinine, and concomitant aspirin use were noted. We conclude that the concomitant use of aspirin with ketorolac is associated with increased renal morbidity in young post-cardiac surgical infants.

Keywords

Ketorolacacute kidney injuryinfantsneonatescardiac surgery
Type
Brief Reports
Information
Cardiology in the Young , Volume 23 , Issue 5 , October 2013 , pp. 752 - 754
Copyright
Copyright © Cambridge University Press 2012 

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