Hostname: page-component-8448b6f56d-c47g7 Total loading time: 0 Render date: 2024-04-19T06:26:25.808Z Has data issue: false hasContentIssue false

Kawasaki disease

Published online by Cambridge University Press:  19 August 2008

Tomisaku Kawasaki*
Affiliation:
Center for Kawasaki Disease, Tokyo
*
Dr. Tomisaku Kawasaki, Center for Kawasaki Disease, Hosaka Building, 1–10 Kanda-Ogawamachi, Chiyoda-Ku, Tokyo 101, Japan

Summary

In this review, I have outlined the clinical picture, epidemiology, pathology, etiology, and current treatment and management of Kawasaki disease. The disease in question has unique features which cannot be classified into any of the categories of conventional pediatric diseases, and thus the elucidation of the etiology and mode of onset may well raise many new medical problems. It is hoped that young practitioners of clinical and fundamental medicine will be able to resolve the problems relating to the disease which remain as quickly as possible.

Type
The World Forum for Pediatric Cardiology Symposium on Kawasaki Disease
Copyright
Copyright © Cambridge University Press 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Kawasaki, T. Febrile oculo-oro-cutaneo-acrodesquamatous syndrome with or without acute non-suppurative cervical lymphadenitis in infancy and childhood: Clinical observa tions, of 50 cases. Jpn J Allergy 1967; 16: 178222. [Japanese]Google ScholarPubMed
2.Kawasaki, T, Kosaki, F, Osawa, S, Shigematsu, I, Yanagawa, S. A new infantile acute febrile mucocutaneous lymph node syn drome prevailing in Japan. Pediatrics 1974; 54: 271276.CrossRefGoogle Scholar
3.Kato, H, Koike, S, Yokoyama, T. Coronary aneurysms in infants and young children with acute febrile mucocutaneous lymph node syndrome. J Pediatr 1975; 86: 892898.CrossRefGoogle ScholarPubMed
4.Nakano, H, Ueda, K, Saito, A, Nojima, M. Repeated quantita tive angiograms in coronary arterial aneurysms in Kawasaki disease. Am J Cardiol 1985; 56: 846851.CrossRefGoogle Scholar
5.Kitamura, S, Kawachi, K, Oyama, C, Miyagi, Y, Morita, R, Koh, Y, Kim, K, Nishii, T. Severe Kawasaki heart disease treated with an internal mammary artery graft in pediatric patients. J Thorac Cardiovasc Surg 1985; 89: 860866.CrossRefGoogle ScholarPubMed
6.Yanagawa, H, Kakamura, Y. Nationwide epidemic of Kawasaki disease in Japan during winter of 1985–1986. Lancet 1986; 2: 11381139.CrossRefGoogle Scholar
7.Fujiwara, H, Fujiwara, E, Takeuchi, E, Hamashima, Y. Clinicopathological study on autopsied Kawasaki disease cases. Shonika 1985; 26: 10291039.Google Scholar
8.Shulman, ST, Rowley, AH. Does Kawasaki disease have a retroviral aetiology? Lancet 1986; 2: 545546.CrossRefGoogle ScholarPubMed
9.Burns, JC, Geha, RS, Schneeberger, EE, Newburger, JW, Rosen, FS, Glezen, LS, Huang, AS, Natale, J, Leung, DYM. Polymerase activity in lymphocyte culture supernatants from patients with Kawasaki disease. Nature 1986; 323: 814816.CrossRefGoogle ScholarPubMed
10.Leung, DYM, Siegel, RL, Grady, S, Krensky, A, Meade, R, Reinherg, EL, Geha, RS. Imrnunoregulatory abnormalities in mucocutaneous lymph node syndrome. Clin Immunol Immunopathol 1982; 23: 100112.CrossRefGoogle ScholarPubMed
11.Leung, DYM, Collins, T, Lapierre, LA, Geha, RS, Pober, JS. Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon. J Clin Invest 1986; 77: 14281435.CrossRefGoogle ScholarPubMed
12.Leung, DYM, Geha, RS, Newburger, JW, Burns, JC, Fiers, W, Lapierre, LA, Pober, JS. Two monokines, Interleukini and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome. J Exp Med 1986; 16: 19581972.CrossRefGoogle Scholar
13.Yanase, Y, Tango, T, Okumura, K, Tada, T, Kawasaki, T. Lymphocyte subsets identified by monoclonal antibodies in healthy children. Pediatr Res 1986; 20: 11471151.CrossRefGoogle ScholarPubMed
14.Hashimoto, Y, Yoshinoya, S, Aikawa, T, Mitamura, T, Miyoshi, Y, Muranaka, M, Miyamoto, T, Yanese, V, Kawasaki, T. Enhanced endothelial cell proliferation in acute Kawasaki disease (Muco-cutaneous lymph node syndrome). Pediatr Res 1986; 20: 943946.CrossRefGoogle ScholarPubMed
15.Yanase, Y, Tango, T, Okumura, K, Tada, T, Kawasaki, T. A comparative study ofalteration in lymphocyte subsets among varicella, hand-foot-and-mouth disease, scarlet fever, measles and Kawasaki Disease. Microbiol Immunol 1987; 31: 701710.CrossRefGoogle ScholarPubMed
16.Furusho, K, Nakano, H, Shinomiya, K, Tamura, T, Manabe, Y, Kawarano, M, Baba, K, Kamiya, T, Kiyosawa, N, Hayashidera, T, Hirose, O, Yokoyama, T, Baba, K, Mori, C. High dose intravenous gammaglobulin for Kawasaki disease. Lancet 1984; 2: 10551058.CrossRefGoogle ScholarPubMed
17.Newburger, JW, Takahashi, M, Burns, JC, Beiser, AS, Chung, KJ, Dully, CE, Glode, MP, Mason, WH, Reddy, V, Sanders, SP, Shulman, ST, Wiggins, JW, Hicks, RV, Aukon, DR, Lewis, AB, Leung, DYM, Colton, T, Rosen, FS, Melish, ME. The treatment of Kawasaki syndrome with intravenous gammaglobulin. N Engl J Med 1986; 315: 341347.CrossRefGoogle Scholar
18.Feigin, RD, Barron, KS. Treatment of Kawasaki syndrome. N Engl J Med 1986; 315: 388390.CrossRefGoogle ScholarPubMed