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Immunosuppressant associated torsades de pointes after acute heart rejection in an 8-year-old boy

Published online by Cambridge University Press:  30 June 2020

Liu Hsin-Ming Open the ORCID record for Liu Hsin-Ming [Opens in a new window] ,
Tseng Wei-Chieh  and
Chiu Shuenn-Nan
Liu Hsin-Ming
Affiliation:
Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan
Tseng Wei-Chieh
Affiliation:
Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan
Chiu Shuenn-Nan*
Affiliation:
Department of Pediatrics, National Taiwan University Children’s Hospital, Taipei, Taiwan
*
Author for correspondence: Dr Chiu Shuenn-Nan, Department of Pediatrics, National Taiwan University Hospital, No. 7, Chung Shan S. Rd. (Zhongshan S. Rd.), Zhongzheng Dist., Taipei10002, Taiwan. Tel: +886 2 23123456#71710; Fax: +886 2 23147450. E-mail: michael@ntuh.gov.tw
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Abstract

Torsades de pointes is a kind of life-threatening ventricular tachyarrhythmia. We report a case of torsades de pointes in an 8-year-old boy with acute rejection after orthotopic heart transplantation. The causes of torsades de pointes could be either congenital or acquired. In this case, various causes including acute rejection-related repolarisation heterogeneity, dose-dependent acquired long QT resulting from treatment with immunosuppressants, and AKAP9 (A-kinase anchoring protein 9) genetic variants are the possible mechanisms.

Keywords

Torsades de pointesgraft rejectionheart transplantation
Type
Brief Report
Information
Cardiology in the Young , Volume 30 , Issue 8 , August 2020 , pp. 1194 - 1195
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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