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Epidemiology of cardiovascular malformations: The state of the art

Published online by Cambridge University Press:  19 August 2008

Charlotte Ferencz  and
Adolofo Correa Villasenñor
Charlotte Ferencz*
Affiliation:
From the Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore
Adolofo Correa Villasenñor*
Affiliation:
Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore
*
Charlotte Ferencz, M.D., M.P.H., Deptartment of Epidemiology and Preventive Medicine, University of Maiyland School of Medicine, Room 146-D, Howard Hall, 660W. Redwood Street, Baltimore, MD 21201 USA. Tel. (301) 328-7864, Fax. (301) 328-8013
Charlotte Ferencz, M.D., M.P.H., Deptartment of Epidemiology and Preventive Medicine, University of Maiyland School of Medicine, Room 146-D, Howard Hall, 660W. Redwood Street, Baltimore, MD 21201 USA. Tel. (301) 328-7864, Fax. (301) 328-8013
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Summary

A historical review highlights an interest in the etiology of birth defects over the course of several centuries and recalls specific hypotheses on the origin of cardiovascular defects postulated 60 years ago. The “State of the Art” of the epidemiology of cardiovascular malformations is characterized by an expanding base of knowledge which holds promise for eventual preventive interventions. Epidemiologic investigations conducted in the past decade have led to an increased understanding of the benefits and problems of studies of populations and of methodologic issues in surveillance of disease and study of risk factors. Comparative evaluations of reported studies to an ongoing population-based case-control investigation (the Baltimore-Washington Infant Study) demonstrate variations in prevalence by time and place, evidence for a strong genetic predisposition to cardiac maldevelopment and new hypotheses regarding environmental risks in the home and place of occupation.

Type
Special Article
Information
Cardiology in the Young , Volume 1 , Issue 4 , October 1991 , pp. 264 - 284
Copyright
Copyright © Cambridge University Press 1991

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