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The effect of Celiac disease on cardiac functions and aortic elasticity parameters in children

Published online by Cambridge University Press:  10 December 2020

Fatos Alkan Open the ORCID record for Fatos Alkan [Opens in a new window] ,
Guzide Dogan ,
Erhun Kasırga  and
Senol Coskun
Fatos Alkan*
Affiliation:
Celal Bayar University, School of Medicine, Division of Pediatric Cardiology, Department of Pediatrics, Manisa, Turkey
Guzide Dogan
Affiliation:
Bezmialem Vakıf University, School of Medicine, Division of Pediatric Gastroenterology, Department of Pediatrics, Istanbul, Turkey
Erhun Kasırga
Affiliation:
Maltepe University, School of Medicine, Division of Pediatric Gastroenterology, Department of Pediatrics, Istanbul, Turkey
Senol Coskun
Affiliation:
Celal Bayar University, School of Medicine, Division of Pediatric Cardiology, Department of Pediatrics, Manisa, Turkey
*
Author for correspondence: Dr. F. Alkan, Celal Bayar University, Medical Faculty, Department of Pediatric, Division of Pediatric Cardiology, 45030, Manisa, Turkey. Tel: +90-(236)-444 4228; Fax: +90-(236)-233 8040. E-mail: fatos.alkan@hotmail.com
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Abstract

Aim:

We aimed to investigate the effect of Celiac disease on myocardial functions and aortic elasticity parameters.

Materials and Methods:

Thirty children with Celiac disease and 30 healthy children were enrolled in the study. Both the groups were similar in terms of age and gender. Cardiac functions of all children in the patients and control group were evaluated using conventional transthoracic echocardiography and tissue Doppler imaging. Aortic strain, distensibility, and stiffness index were calculated by M-mode echocardiography.

Results:

The demographic findings, height, weight, and body mass index of cases were similar among two groups. No statistical difference was found between E wave velocity for conventional transthoracic echocardiography and tissue Doppler imaging measurements of the mitral valve; early diastolic flow peak velocity, A wave velocity; late diastolic flow peak velocity; and E/A ratio. Isovolumetric relaxation time and isovolumetric contraction time ratios were statistically different between the groups (p = 0.000, p = 0.000, p = 0.000). The myocardial performance index calculated according to the pulse Doppler measurement results was found to be statistically different between the groups (p = 0.000). There was no statistical difference between the groups in terms of aortic strain, distensibility, and stiffness index.

Conclusion:

In this study, both conventional transthoracic echocardiography and tissue Doppler imaging revealed the affection of the myocardial functions during systole and diastole in children with Celiac disease. Therefore, early follow-up and routine cardiac evaluation of celiac patients may be appropriate due to the increased risk of cardiac affection.

Keywords

Celiac diseasetissue Doppler echocardiographymyocardial performance index
Type
Original Article
Information
Cardiology in the Young , Volume 31 , Issue 4 , April 2021 , pp. 627 - 630
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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