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Do platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have a predictive value on pediatric extracorporeal membrane oxygenation (ECMO) results?

Part of: Surgery

Published online by Cambridge University Press:  21 May 2021

Ergin Arslanoğlu ,
Nihat Çine ,
Kenan Abdurrahman Kara Open the ORCID record for Kenan Abdurrahman Kara [Opens in a new window] ,
Eylem Tunçer ,
Fatma Ukil Işıldak ,
Yasemin Yavuz ,
Abdullah Arif Yılmaz ,
Fatih Tomrukcu ,
Cuneyt Arkan  and
Fatih Yigit
...Show all authors
Ergin Arslanoğlu
Affiliation:
Pediatric Cardiovascular Surgery Department, Kartal Kosuyolu High Education and Training Hospital, Cevizli Kavşağı, Turkey
Nihat Çine
Affiliation:
Pediatric Cardiovascular Surgery Department, Kartal Kosuyolu High Education and Training Hospital, Cevizli Kavşağı, Turkey
Kenan Abdurrahman Kara*
Affiliation:
Pediatric Cardiovascular Surgery Department, Kartal Kosuyolu High Education and Training Hospital, Cevizli Kavşağı, Turkey
Eylem Tunçer
Affiliation:
Pediatric Cardiovascular Surgery Department, Kartal Kosuyolu High Education and Training Hospital, Cevizli Kavşağı, Turkey
Fatma Ukil Işıldak
Affiliation:
Pediatric Cardiovascular Anesthesia and Reanimation Department, Kartal Kosuyolu High Education and Training Hospital, Cevizli Kavşağı, Turkey
Yasemin Yavuz
Affiliation:
Pediatric Cardiovascular Anesthesia and Reanimation Department, Kartal Kosuyolu High Education and Training Hospital, Cevizli Kavşağı, Turkey
Abdullah Arif Yılmaz
Affiliation:
Pediatric Cardiovascular Surgery Department, Kartal Kosuyolu High Education and Training Hospital, Cevizli Kavşağı, Turkey
Fatih Tomrukcu
Affiliation:
Pediatric Cardiovascular Surgery Department, Kartal Kosuyolu High Education and Training Hospital, Cevizli Kavşağı, Turkey
Cuneyt Arkan
Affiliation:
Pediatric Cardiovascular Surgery Department, Kartal Kosuyolu High Education and Training Hospital, Cevizli Kavşağı, Turkey
Fatih Yigit
Affiliation:
Pediatric Cardiovascular Surgery Department, Kartal Kosuyolu High Education and Training Hospital, Cevizli Kavşağı, Turkey
Hakan Ceyran
Affiliation:
Pediatric Cardiovascular Surgery Department, Kartal Kosuyolu High Education and Training Hospital, Cevizli Kavşağı, Turkey
*
Author for correspondence: K. A. Kara, Pediatric Cardiovascular Surgery Department, Kartal Kosuyolu High Education and Training Hospital, Cevizli, 2, Denizer Caddesi, Cevizli Kavşağı, 34865Kartal, İstanbul, Turkey. Tel: +9053006552251. E-mail: kenankaradoc@gmail.com
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Abstract

Background:

It is difficult to predict the complications and prognosis of ECMO, which is gaining widespread use in patients with pediatric surgery. Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are emerging inflammatory markers that can be calculated from complete blood count, which is a cheap and easily accessible laboratory analysis. The ratios between cellular elements in peripheral blood have been demonstrated to provide information on inflammation, infection, and immune response.

Methods:

Sixty-seven patients who needed ECMO application after undergoing pediatric cardiovascular surgery in our clinic, between May 2005 and April 2020, were included in this study. The age of patients varied between 4 days and 17 years with a mean of 30.59 ± 147.26 months.

Results:

The relationships between PLR or NLR values and various blood parameters and blood gas results were found to be statistically nonsignificant in our group of pediatric ECMO recipients. Even if the effect of PLR and NLR values on mortality and prognosis is statistically nonsignificant in patients who need ECMO after congenital heart surgery, PLR and NLR are typically elevated in the postoperative period. An increase in these values above a certain threshold may be a statistically significant indicator for the prediction of mortality.

Conclusions:

There are few studies in the literature concerning PLR and NLR values in patients with pediatric heart surgery. We consider this study will make way for new studies in the future.

Keywords

Platelet-to-lymphocyte rationeutrophil-to-lymphocyte ratiopediatric ECMOvasoactive-inotropic score
Type
Original Article
Information
Cardiology in the Young , Volume 31 , Issue 6 , June 2021 , pp. 1003 - 1008
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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