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Correlation of P-wave dispersion with insulin sensitivity in obese adolescents

Published online by Cambridge University Press:  08 April 2016

Ahmet Sert ,
Eyup Aslan ,
Muammer Buyukınan  and
Ozgur Pirgon
Ahmet Sert*
Affiliation:
Department of Paediatric Cardiology, Konya Training and Research Hospital, Konya, Turkey
Eyup Aslan
Affiliation:
Department of Paediatric Cardiology, Denizli State Hospital, Denizli, Turkey
Muammer Buyukınan
Affiliation:
Department of Paediatric Endocrinology, Konya Training and Research Hospital, Konya, Turkey
Ozgur Pirgon
Affiliation:
Department of Paediatric Endocrinology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
*
Correspondence to: A. Sert, Department of Paediatric Cardiology, Konya Training and Research Hospital, 42080 Konya, Turkey. Tel: +90 332 323 6709; Fax: +90 332 323 6723; E-mail: ahmetsert2@hotmail.com
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Abstract

Background

P-wave dispersion is a new and simple electrocardiographic marker that has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. In the present study, we evaluated P-wave dispersion in obese adolescents and investigated the relationship between P-wave dispersion, cardiovascular risk factors, and echocardiographic parameters.

Methods

We carried out a case–control study comparing 150 obese adolescents and 50 healthy controls. Maximum and minimum P-wave durations were measured using a 12-lead surface electrocardiogram, and P-wave dispersion was calculated as the difference between these two measures. Echocardiographic examination was also performed for each subject. Multivariate linear regression analysis with stepwise variable selection was used to evaluate parameters associated with increased P-wave dispersion in obese subjects.

Results

Maximum P-wave duration and P-wave dispersion were significantly higher in obese adolescents than control subjects (143±19 ms versus 117±20 ms and 49±15 ms versus 29±9 ms, p<0.0001 for both). P-wave dispersion was positively correlated with body mass index, waist and hip circumferences, systolic and diastolic blood pressures, total cholesterol, serum levels of low-density lipoprotein cholesterol, triglycerides, glucose, and insulin, homoeostasis model assessment for insulin resistance score, left ventricular mass, and left atrial dimension. P-wave dispersion was negatively correlated with high-density lipoprotein cholesterol levels. By multiple stepwise regression analysis, left atrial dimension (β: 0.252, p=0.008) and homoeostasis model assessment for insulin resistance (β: 0.205; p=0.009) were independently associated with increased P-wave dispersion in obese adolescents.

Conclusions

Insulin resistance is a significant, independent predictor of P-wave dispersion in obese adolescents.

Keywords

AdolescentelectrocardiogramobesityP-wave dispersion
Type
Original Articles
Information
Cardiology in the Young , Volume 27 , Issue 2 , March 2017 , pp. 229 - 235
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Copyright
© Cambridge University Press 2016 

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