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Assessment of cardiac functions using tissue Doppler imaging in children with familial Mediterranean fever

Published online by Cambridge University Press:  19 August 2011

Osman Ozdemir ,
Pinar Isik Agras ,
Yusuf Aydin ,
Ayhan Abaci ,
Samil Hizli ,
Halil Ibrahim Akkus  and
Cihan Fidan
Osman Ozdemir*
Affiliation:
Department of Paediatric Cardiology, Kecioren Training and Research Hospital, Ankara, Turkey
Pinar Isik Agras
Affiliation:
Department of Paediatric Nephrology, Kecioren Training and Research Hospital, Ankara, Turkey
Yusuf Aydin
Affiliation:
Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey
Ayhan Abaci
Affiliation:
Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey
Samil Hizli
Affiliation:
Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey
Halil Ibrahim Akkus
Affiliation:
Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey
Cihan Fidan
Affiliation:
Department of Paediatrics, Kecioren Training and Research Hospital, Ankara, Turkey
*
Correspondence to: Dr O. Ozdemir, Pinarbasi Mahallesi, Sanatoryum Caddesi, Ardahan Sokak, Kecioren Egitim ve Arastirma Hastanesi (Kecioren Training and Research Hospital), Kecioren, Ankara 06380, Turkey. Tel: +90 312 356 90 00; Fax: +90 312 356 90 02; E-mail: pedkard@gmail.com
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Abstract

Objective

Familial Mediterranean fever may carry a potential for cardiovascular disorders because of sustained inflammation during its course; however, there has been a limited number of studies investigating the cardiac functions in children. The aim of this study was to assess both ventricular diastolic functions using conventional echocardiography and tissue Doppler imaging in children with familial Mediterranean fever.

Patients and methods

The study population included 25 patients with familial Mediterranean fever – mean age was 11.8 plus or minus 5.30 years – and 23 healthy patients as controls – mean age was 9.88 plus or minus 3.69 years. Both ventricular functions were measured using echocardiography comprising standard M-mode and conventional Doppler and tissue Doppler imaging during an attack-free period.

Results

The conventional echocardiographic parameters with myocardial performance index were in normal ranges and similar in patients with familial Mediterranean fever and controls, with a p-value more than 0.05. However, right ventricular diastolic dysfunction was observed in patients with familial Mediterranean fever documented by tissue Doppler imaging, with a p-value less than 0.05 for E't and A't wave ratio.

Conclusion

Using tissue Doppler imaging, we have demonstrated that although left ventricular functions were comparable in the patients and healthy children, right ventricular diastolic function indices were impaired in patients with familial Mediterranean fever during childhood. Impaired right ventricular diastolic function may be an early manifestation of cardiac involvement in children with familial Mediterranean fever.

Keywords

Cardiac functionchildrenechocardiographyfamilial Mediterranean fevertissue Doppler imaging
Type
Original Articles
Information
Cardiology in the Young , Volume 22 , Issue 2 , 02 March 2012 , pp. 188 - 193
Copyright
Copyright © Cambridge University Press 2011

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