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Assessing autonomic activity and prognostic risk factors comparing multisystem inflammatory syndrome and isolated viral myocarditis/myopericarditis

Published online by Cambridge University Press:  02 February 2024

Derya Duman Open the ORCID record for Derya Duman [Opens in a new window] ,
Derya Karpuz ,
Bahar Taşdelen  and
Necdet Kuyucu
Derya Duman*
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Mersin University, Mersin, Turkey
Derya Karpuz
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Mersin University, Mersin, Turkey
Bahar Taşdelen
Affiliation:
Department of Biostatistics and Medical Informatics, Faculty of Medicine, Mersin University, Mersin, Turkey
Necdet Kuyucu
Affiliation:
Department of Pediatric Infectious Disease, Faculty of Medicine, Mersin University, Mersin, Turkey
*
Corresponding author: D. Duman; Email: drderyaduman@gmail.com
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Abstract

Introduction and aim:

In pediatric multisystem inflammatory syndrome and isolated viral myocarditis/myopericarditis, autonomic nervous system function can be evaluated by a non-invasive method called heart rate variability. This study aims to evaluate heart rate variability in these two groups by comparing them with each other. This is the first study assessing these values in these two groups of patients.

Method:

Patients who are diagnosed with multisystem inflammatory syndrome in children and isolated viral myocarditis/myopericarditis at a university hospital from September 2021 to February 2023 are screened by electrocardiography, echocardiography, and 24-hour Holter monitoring. A healthy control group, compatible in age and gender with the patient groups, was selected from healthy subjects that applied to the hospital for palpitation, murmur, and/or chest pain. Heart rate variability parameters and related laboratory markers were analyzed and compared among the three groups.

Results:

There were 30 patients with multisystem inflammatory syndrome in children, 43 patients with isolated viral myocarditis/myopericarditis, and 109 participants in the healthy control group. Statistically significant differences were found in most of the heart rate variability parameters: standard deviation of normal to normal intervals (SDNN), the mean of the 5- minute RR interval standard deviations (SDNNİ), the standard deviation of 5-minute R wave to R wave(RR) interval means (SDANN), the root mean square of successive RR interval differences (RMSSD), and the percentage of the beats with a consecutive RR interval difference of more than 50 ms (pNN50%), very low frequency, high frequency, low frequency, triangular index, and low frequency/high-frequency ratio. Multisystem inflammatory syndrome in children patients had impaired and declined heart rate variability values compared to the other two groups. In patients with myocarditis/myopericarditis, we couldn’t find a significant difference in these parameters with the control group.

Conclusion:

Heart rate variability can be used as an important non-invasive autonomic function parameter in determining prognosis and treatment plans, especially in patients diagnosed with multisystem inflammatory syndrome in children. This impairment of autonomic activity could be more prominent in patients with decreased left ventricular systolic functions.

Keywords

arrhythmiaautonomic nervous systemheart rate variabilitymultisystem inflammationmyocarditis
Type
Original Article
Information
Cardiology in the Young , Volume 34 , Issue 2 , February 2024 , pp. 421 - 427
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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