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Relationship between homocysteine and chronic total coronary occlusion: a cross-sectional study from southwest China

Published online by Cambridge University Press:  09 October 2023

Kaiyong Xiao*
Affiliation:
Department of Cardiology, Guangyuan Central Hospital, Guangyuan, SC, China
Zhe Xv
Affiliation:
Department of Pediatric Medicine, Guangyuan Central Hospital, Guangyuan, SC, China
Liang Liu
Affiliation:
Department of Cardiology, The Second Hospital of Shanxi Medical University, Taiyuan, SX, China
Bin Yang
Affiliation:
Department of Cardiology, The Second Hospital of Shanxi Medical University, Taiyuan, SX, China
Huili Cao
Affiliation:
Department of Cardiology, The Second Hospital of Shanxi Medical University, Taiyuan, SX, China
Jianping Wang
Affiliation:
Department of Cardiology, Guangyuan Central Hospital, Guangyuan, SC, China
Yuling Xv
Affiliation:
Sterilization Supply Center, Guangyuan Central Hospital, Guangyuan, SC, China
Qingrui Li
Affiliation:
Department of Cardiology, Guangyuan Central Hospital, Guangyuan, SC, China
Yulin Hou
Affiliation:
Department of Cardiology, Guangyuan Central Hospital, Guangyuan, SC, China
Feifei Feng
Affiliation:
Department of Cardiology, Guangyuan Central Hospital, Guangyuan, SC, China
Jie Wang
Affiliation:
Department of Cardiology, Guangyuan Central Hospital, Guangyuan, SC, China
Hui Feng
Affiliation:
Medical Laboratory Center, Guangyuan Central Hospital, Guangyuan, SC, China
*
Corresponding author: K. Xiao; Email: keyea1@126.com

Abstract

Background:

Chronic total coronary occlusion is among the most complex coronary artery diseases. Elevated homocysteine is a risk factor for coronary artery diseases. However, few studies have assessed the relationship between homocysteine and chronic total coronary occlusion.

Methods:

1295 individuals from Southwest China were enrolled in the study. Chronic total coronary occlusion was defined as complete occlusion of coronary artery for more than three months. Homocysteine was divided into quartiles according to its level. Univariate and multivariate logistic regression models, receiver operating characteristic curves, and subgroup analysis were applied to assess the relationship between homocysteine and chronic total coronary occlusion.

Results:

Subjects in the higher homocysteine quartile had a higher rate of chronic total coronary occlusion (P < 0.001). After adjustment, the odds ratio for chronic total coronary occlusion in the highest quartile of homocysteine compared with the lowest was 1.918 (95% confidence interval 1.237–2.972). Homocysteine ≥ 15.2 μmol/L was considered an independent indicator of chronic total coronary occlusion (odds ratio 1.53, 95% confidence interval 1.05–2.23; P = 0.0265). The area under the receiver operating characteristic curve was 0.659 (95% confidence interval, 0.618–0.701; P < 0.001). Stronger associations were observed in elderly and in those with hypertension and diabetes.

Conclusions:

Elevated homocysteine is significantly associated with chronic total coronary occlusion, particularly in elderly and those with hypertension and diabetes.

Type
Original Article
Copyright
© The Author(s), 2023. Published by Cambridge University Press

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