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Impact of obstructive sleep apnoea on cardiovascular outcomes and mortality in young adults with congenital heart anomalies: insights from the national inpatient sample (2019)

Published online by Cambridge University Press:  05 March 2024

Ankit Vyas Open the ORCID record for Ankit Vyas [Opens in a new window] ,
Rupak Desai Open the ORCID record for Rupak Desai [Opens in a new window] ,
Nitin Ghadge ,
Prerna Bansal ,
Harika Varma Chintalapalli Patta ,
Maharshi Raval ,
Akhil Jain ,
Tripti Gupta ,
Harshil Patel  and
Ashok Kondur
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Ankit Vyas
Affiliation:
Department of Vascular Medicine, Ochsner Clinic Foundation, New Orleans, LA, USA
Rupak Desai
Affiliation:
Independent Researcher, Atlanta, GA, USA
Nitin Ghadge
Affiliation:
Independent Researcher, Atlanta, GA, USA
Prerna Bansal
Affiliation:
Department of Medicine, Rural Medical College, Pravara Institute of Medical Sciences, Loni, MH, India
Harika Varma Chintalapalli Patta
Affiliation:
Department of Internal Medicine, Baptist Hospitals of Southeast Texas, Beaumont, TX, USA
Maharshi Raval
Affiliation:
Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Akhil Jain
Affiliation:
Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Tripti Gupta
Affiliation:
Divison of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Harshil Patel
Affiliation:
Department of Cardiovascular Disease, Ascension Providence Hospital, Southfield, MI, USA
Ashok Kondur
Affiliation:
Department of Cardiovascular Disease, Garden City Hospital, Garden City, MI, USA
Carl J. Lavie*
Affiliation:
John Ochsner Heart and Vascular Institute, Ochsner Clinical School, University of Queensland School of Medicine, New Orleans, LA, USA
*
Corresponding author: C. J. Lavie; Email: clavie@ochsner.org
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Abstract

Background:

Obstructive sleep apnoea is a common sleep disorder, and adult congenital heart disease (CHD) is also a significant burden on the population. Early diagnosis and treatment are important for improving quality of life and reducing the risk of health complications. The limited research on obstructive sleep apnoea and adult CHD highlights the need for further investigation into the relationship between these two conditions and the mechanisms underlying this relationship.

Method:

We used NIS 2019 database to identify adult CHD admissions aged 18–44 years and assess the impact of obstructive sleep apnoea on all-cause mortality, dysrhythmia, and stroke. A propensity-matched cohort of individuals with and without obstructive sleep apnoea was obtained, and the outcomes were assessed using multivariable analysis and compared in terms of resource utilisation.

Results:

Of the 41,950 young adult CHD admissions, 6.3% (n = 2630) had obstructive sleep apnoea. The obstructive sleep apnoea+ (n = 2590) and obstructive sleep apnoea− (n = 2590) cohorts were comparable in terms of median age (35 years) and were predominantly male (63.1% versus 62.5%). The obstructive sleep apnoea+ cohort had a higher frequency of risk factors like chronic obstructive pulmonary disease, hypothyroidism, and prior venous thromboembolism than the obstructive sleep apnoea cohort. We found significant association of obstructive sleep apnoea with dysrhythmia (adjusted odds ratio 2.99, 95% confidence interval 2.13–4.19, p < 0.001), but no significant impact on the risk of all-cause mortality or stroke. The obstructive sleep apnoea+ cohort also had higher transfers to short-term facilities, prolonged stays, and higher charges (p < 0.001).

Conclusion:

Our study provides important insights into relationship between obstructive sleep apnoea and adult CHD and highlights the need for further investigation into the impact of obstructive sleep apnoea on individuals with adult CHD.

Keywords

Obstructive sleep apnoeaadult CHD
Type
Original Article
Information
Cardiology in the Young , First View , pp. 1 - 5
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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