Hostname: page-component-7479d7b7d-c9gpj Total loading time: 0 Render date: 2024-07-10T22:27:02.092Z Has data issue: false hasContentIssue false
  • English
  • Français

Suppression of Spreading Depression of Leão in Neocortex by an N-Methyl-D-Aspartate Receptor Antagonist

Published online by Cambridge University Press:  18 September 2015

Richard S. McLachlan
Richard S. McLachlan*
Affiliation:
Departments of Clinical Neurological Sciences and Physiology, The University of Western Ontario, London
*
Epilepsy Unit, University Hospital, 339 Windermere Rd., London, Ontario, Canada N6A 5A5
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Spreading depression has been implicated in the pathophysiology of a number of diseases such as migraine, stroke and epilepsy. The characteristics of this phenomenon were explored in neocortex of anesthetized rats. Spreading depression was produced in 10 of 15 animals using mechanical, electrical and chemical stimulation. Mean amplitude of the DC shift was -9.3 mV, mean duration at any one electrode 65 sec and rate of spread 2-5 mm/min. Spreading depression was facilitated by focal interictal spike activity induced by penicillin and completely blocked by the N-methyl-D-aspartate (NMDA) receptor antagonist, DL-2-aminophosphonovaleric acid (APV), providing further evidence that excitatory amino acid neurotransmission is a critical element in the development or propagation of the phenomenon.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 4 , November 1992 , pp. 487 - 491
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

References

REFERENCES

1.Leão, AAP.Spreading depression of activity in the cerebral cortex. J Neurophysiol 1944; 7: 359–390.CrossRefGoogle Scholar
2.Leão, AAP.Further observations on the spreading depression of activity in the cerebral cortex. J Neurophysiol 1947; 10: 409–414.CrossRefGoogle ScholarPubMed
3.Welch, KM, D’Andrea, G, Tepley, N, et al. The concept of migraine as a state of central neuronal hyperexcitability. Neurol Clin 1990; 8: 817–828.CrossRefGoogle ScholarPubMed
4.Lauritzen, M.Cortical spreading depression as a putative migraine mechanism. Trends Neurosci 1987; 10: 8–12.CrossRefGoogle Scholar
5.Somjen, GG, Aitken, PG, Balestrino, M, et al. Spreading depression-like depolarization and selective vulnerability of neurons. A brief review. Stroke 1990; 21: 179–183.Google ScholarPubMed
6.Marshall, WH.Spreading cortical depression of Leão. Physiol Rev 1959; 39: 239–279.CrossRefGoogle ScholarPubMed
7.Olesen, J, Jorgensen, MB.Leao’s spreading depression in the hippocampus explains transient global amnesia. A hypothesis. Acta Neurol Scand 1986; 73: 219–220.CrossRefGoogle ScholarPubMed
8.Oka, H, Kako, M, Matsushima, M, et al. Traumatic spreading depression syndrome. Review of a particular type of head injury in 37 patients. Brain 1977; 100: 287–298.CrossRefGoogle ScholarPubMed
9.Van Harreveld, A, Kooiman, M.Amino acid release from the cerebral cortex during spreading depression and asphyxiation. J Neurochem 1965; 12: 431–439.CrossRefGoogle Scholar
10.Van Harreveld, A, Fifkova, E.Glutamate release from the retina during spreading depression. J Neurobiol 1970; 2: 13–29.CrossRefGoogle ScholarPubMed
11.Gardino, PF, DoCarmo, RJ.Glutamate and spreading depression in chick retina. An Acad Bras Ciênc 1983; 55: 297–307.Google ScholarPubMed
12.Gorelova, NA, Koroleva, VI, Amemori, T, et al. Ketamine blockade of cortical spreading depression in rats. Electroencephalogr Clin Neurophysiol 1987; 66: 440–447.CrossRefGoogle ScholarPubMed
13.Mody, I, Lambert, JDC, Heinemann, U.Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices. J Neurophysiol 1987; 57: 869–888.CrossRefGoogle ScholarPubMed
14.Marrannes, R, Willems, R, DePrins, E, et al. Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat. Brain Res 1988; 457: 226–240.CrossRefGoogle ScholarPubMed
15.Koroleva, VI, Bures, J.Cortical penicillin focus as a generator of receptive spike-triggered waves of spreading depression in rats. Exp Brain Res 1983; 51: 291–297.CrossRefGoogle Scholar
16.Mahnke, JH, Ward, AA.Standing potential characteristics of the epileptogenic focus. Epilepsia 1961; 2: 161–169.Google ScholarPubMed
17.Ochs, S.The nature of spreading depression in neural networks. Int Rev Neurobiol 1962; 4: 1–69.CrossRefGoogle Scholar
18.Vinogradova, LV, Koroleva, VI, Bures, J.Re-entry waves of Leao’s spreading depression between neocortex and caudate nucleus. Brain Res 1991, 538: 161–164.CrossRefGoogle ScholarPubMed
19.Haglund, MM, Schwartzkroin, PA.Role of Na-K pump potassium regulation and IPSPs in seizures and spreading depression in immature rabbit hippocampal slices. J Neurophysiol 1990; 63: 225–239.CrossRefGoogle ScholarPubMed
20.Goldensohn, ES.Experimental seizure mechanisms. In: Jasper, HH, Ward, AA, Pope, A, eds. Basic Mechanisms of the Epilepsies. Boston: Little, Brown & Co. 1969; 289–298.Google Scholar
21.Sugaya, E, Takato, M, Noda, Y.Neuronal and glial activity during spreading depression in cerebral cortex of cat. J Neurophysiol 1975; 38: 822–841.CrossRefGoogle ScholarPubMed
22.Snow, RW, Taylor, CP, Dudek, FE.Electrophysiological and optical changes in slices of rat hippocampus during spreading depression. J Neurophysiol 1983; 50: 561–572.CrossRefGoogle ScholarPubMed
23.Grafstein, B.Mechanism of spreading cortical depression. J Neurophysiol 1956; 19: 154–171.CrossRefGoogle ScholarPubMed
24.Gardner-Medwin, AR.Possible roles of vertebrate neuroglia in potassium dynamics, spreading depression and mygraine. J Exp Biol 1981; 95: 111–127.CrossRefGoogle Scholar
25.Vyskocil, F, Kruz, N, Bures, J.Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in rats. Brain Res 1982; 39: 255–259.CrossRefGoogle Scholar
26.Heinemann, U, Lux, HD, Gutnick, MJ.Extracellular free calcium and potassium during paroxysmal activity in the cerebral cortex of the cat. Exp Brain Res 1977; 17: 237–243.Google Scholar
27.Curtis, DR, Watkins, JC.Analogs of glutamic and gamma-amino-N-butyric acids having potent actions on mammalian neurons. Nature 1961; 191: 1010–1011.CrossRefGoogle Scholar
28.Szerb, JC.Glutamate release and spreading depression in the fascia dentata in response to microdialysis with high K+: role of glia. Brain Res 1991; 542: 259–265.CrossRefGoogle Scholar
29.Anderson, WW, Swartzwelder, HS, Wilson, WA.The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice. J Neurophysiol 1987; 57: 1–21.CrossRefGoogle Scholar
30.Davies, J, Francis, AA, Jones, AW, Watkins, JC.2-amino-5 phospho-novalerate (2APV), a potent and selective antagonist of amino acid induced and synaptic excitation. Neurosci Lett 1981; 21: 77–81.CrossRefGoogle ScholarPubMed
31.Brocher, S, Artola, A, Singer, W.Intracellular injection of Ca2+ chelators blocks induction of long-term depression in rat visual cortex. Proc Natl Acad Sci 1992; 89: 123–127.CrossRefGoogle ScholarPubMed
32.Croucher, MJ, Collins, JF, Meidrum, BS.Anticonvulsant action of excitatory amino acid antagonists. Science 1982; 216: 899–901.CrossRefGoogle ScholarPubMed
33.Avoli, M, Drapeau, C, Louvei, , et al. Epileptiform activity induced by low extracellular magnesium in the human cortex maintained in vitro. Ann Neurol 1991; 30: 589–596.Google Scholar
34.Simon, RP, Swan, JH, Griffiths, T, et al. Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage to the brain. Science 1984; 226: 850–852.Google Scholar