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Spinocerebellar Ataxia Type 12 was not Found in Korean Parkinsonian Patients

Published online by Cambridge University Press:  02 December 2014

Jin Whan Cho
Affiliation:
BK21 NRI and CRI, College of Medicine, Seoul National University, Seoul, South Korea Metropolitan Boramae Hospital, Seoul, South Korea
Sung Yeon Kim
Affiliation:
Department of Laboratory Medicine, Seoul National University, Seoul, South Korea BK21 NRI and CRI, College of Medicine, Seoul National University, Seoul, South Korea Seoul National University Hospital, Seoul, South Korea
Sung Sup Park
Affiliation:
Department of Laboratory Medicine, Seoul National University, Seoul, South Korea BK21 NRI and CRI, College of Medicine, Seoul National University, Seoul, South Korea Seoul National University Hospital, Seoul, South Korea
Beom S. Jeon*
Affiliation:
BK21 NRI and CRI, College of Medicine, Seoul National University, Seoul, South Korea
*Corresponding
Department of Neurology, Seoul National University College of Medicine, 28 Yeongeon-Dong, Jongno-Gu, Seoul 110-744, South Korea.
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Abstract

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Background:

Parkinsonism (PD) is occasionally seen in several types of spinocerebellar ataxia (SCA). Mutations in SCA gene have been reported in the patients of parkinsonism without ataxia.

Methods:

We examined spinocerebellar ataxia type 12 mutation in 877 PD and 199 multiple system atrophy (MSA) patients.

Results and Conclusions:

No patients showed abnormal SCA12 expansion. It suggests that PD and MSA are not associated with SCA12 and it is not necessary to screen SCA12 in PD and MSA patients.

Résumé:

RÉSUMÉ: Contexte:

On observe parfois du parkinsonisme dans plusieurs types d’ataxies spinocérébelleuses (SCA). Des mutations du gène de la SCA ont été rapportées chez des patients présentant du parkinsonisme sans ataxie.

Méthodes:

Nous avons recherché ces mutations chez 877 patients parkinsoniens et chez 199 patients atteints d’atrophie multisystémique.

Résultats et conclusions:

Aucun patient n’était porteur d’une expansion anormale du gène de la SCA de type 12. Ceci porte à croire que la maladie de Parkinson et l’atrophie multisystémique ne sont pas associées au gène de la SCA 12 et qu’il n’est pas nécessaire d’en faire le dépistage chez les patients atteints de la maladie de Parkinson et de l’atrophie multisystémique.

Type
Original Articles
Copyright
Copyright © The Canadian Journal of Neurological 2008

References

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