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Reversible Splenial Lesion Following Rapid Withdrawal of Carbamazepine

Published online by Cambridge University Press:  20 October 2014

David Pelz ,
Tae-Won Kim ,
In-Seok Park  and
Joong-Seok Kim
David Pelz
Affiliation:
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea
Tae-Won Kim
Affiliation:
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea
In-Seok Park
Affiliation:
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea
Joong-Seok Kim*
Affiliation:
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea
*
Department of Neurology, Seoul St. Mary's Hospital, The Catholic University of Korea, 505, Banpo-dong, Seocho-gu, Seoul 137-701, Korea. Email: neuronet@catholic.ac.kr.
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A 19-year-old man with paroxysmal kinesigenic dyskinesia (PKD) taking 200mg carbamazepine per day for six years was admitted to our hospital because of a medical certificate for soldiers. The dyskinesias were usually precipitated by sudden movements and these attacks occurred several times a day and had a brief duration (less than one minute). The drug was abruptly withdrawn seven days before the brain imaging and video-electroencephalography monitoring. Magnetic resonance imaging showed cytotoxic edema in the splenium, which were completely resolved three months later (Figure).

Type
Neuroimaging Highlight
Information
Canadian Journal of Neurological Sciences , Volume 41 , Issue 4 , July 2014 , pp. 504 - 505
Copyright
Copyright © The Canadian Journal of Neurological 2014

References

1.Mori, H, Maeda, M, Takanashi, J, et al. Reversible splenial lesion in the corpus callosum following rapid withdrawal of carbamazepine after neurosurgical decompression for trigeminal neuralgia. J Clin Neuro sci 2012;19(8):1182–4.CrossRefGoogle ScholarPubMed
2.Gürtler, S, Ebner, A, Tuxhorn, I, Ollech, I, Pohlmann-Eden, B, Woermann, FG.Transient lesion in the splenium of the corpus callosum and antiepileptic drug withdrawal. Neurology 2005;65(7):1032–6.CrossRefGoogle ScholarPubMed