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PS2 - 197 DICER Governs Characteristics of Glioma Stem Cells and the Resulting Tumors in Xenograft Mouse Models of GBM
Published online by Cambridge University Press: 18 October 2016
Abstract
The RNAse III endonuclease DICER is a key regulator of microRNA (miRNA) biogenesis and is frequently down-regulated in a variety of malignancies. We characterized the role of Dicer in glioblastoma (GB), specifically demonstrating its effects on the ability of glioma stem-like cells to form tumors in a mouse model of GB. DICER silencing in glioma stem-like cells (GSCs) reduced their stem cell characteristics, while tumors arising from these cells were more aggressive, larger in volume, and displayed a higher proliferation index and lineage differentiation. The resulting tumors, however, were more sensitive to radiation treatment. Our results demonstrate that DICER affects the tumorigenic potential of GSCs, providing a platform for analysis of specific relevant miRNAs and development of potentially novel therapies against GB.
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- Information
- Canadian Journal of Neurological Sciences , Volume 43 , Supplement S4: ABSTRACTS: 17th Biennial Canadian Neuro-Oncology Meeting , October 2016 , pp. S15
- Copyright
- Copyright © The Canadian Journal of Neurological Sciences Inc. 2016