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PS1 -125 Assessment of Function and Quality of Life in a Phase II Multi-Institutional Clinical Trial of Fractionated Simultaneous In-Field Boost Radiotherapy for Patients with 1-2 Brain Metastases

Published online by Cambridge University Press:  18 October 2016

G Bauman*
Affiliation:
Division of Radiation Oncology, London Health Sciences Centre, A4-901B, 790 Commissioners Rd. E, London, ON
S Yartsev
Affiliation:
Division of Radiation Oncology, London Health Sciences Centre, A4-901B, 790 Commissioners Rd. E, London, ON
D Roberge
Affiliation:
Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC
R. MacRae
Affiliation:
Division of Radiation Oncology, University of Ottawa, Ottawa, ON
W Roa
Affiliation:
Department of Radiation Oncology, Cross Cancer Institute, Edmonton, AB
V Panet-Raymond
Affiliation:
Department of Radiation Oncology, McGill University Health Centre, Montreal, QC
L Masucci
Affiliation:
Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC
B Yaremko
Affiliation:
Division of Radiation Oncology, London Health Sciences Centre, A4-901B, 790 Commissioners Rd. E, London, ON
D. D’Souza
Affiliation:
Division of Radiation Oncology, London Health Sciences Centre, A4-901B, 790 Commissioners Rd. E, London, ON
D. Palma
Affiliation:
Division of Radiation Oncology, London Health Sciences Centre, A4-901B, 790 Commissioners Rd. E, London, ON
T. Sexton
Affiliation:
Division of Radiation Oncology, London Health Sciences Centre, A4-901B, 790 Commissioners Rd. E, London, ON
E. Yu
Affiliation:
Division of Radiation Oncology, London Health Sciences Centre, A4-901B, 790 Commissioners Rd. E, London, ON
J.R. Pantarotto
Affiliation:
Division of Radiation Oncology, University of Ottawa, Ottawa, ON
B. Ahmad
Affiliation:
Division of Radiation Oncology, London Health Sciences Centre, A4-901B, 790 Commissioners Rd. E, London, ON
B. Fisher
Affiliation:
Division of Radiation Oncology, London Health Sciences Centre, A4-901B, 790 Commissioners Rd. E, London, ON
A.R. Dar
Affiliation:
Division of Radiation Oncology, London Health Sciences Centre, A4-901B, 790 Commissioners Rd. E, London, ON
C. Lambert
Affiliation:
Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC
G. Pond
Affiliation:
Department of Oncology, Department of Oncology, McMaster University, Hamilton, ON
L. Stitt
Affiliation:
Division of Radiation Oncology, London Health Sciences Centre, A4-901B, 790 Commissioners Rd. E, London, ON
K.Y. Tay
Affiliation:
Department of Diagnostic Radiology, London Health Sciences Centre, London, ON
G. Rodrigues
Affiliation:
Division of Radiation Oncology, London Health Sciences Centre, A4-901B, 790 Commissioners Rd. E, London, ON
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Abstract

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We examined functional outcomes and quality of life of whole brain radiotherapy (WBRT) with integrated fractionated stereotactic radiotherapy boost (FSRT) for brain metastases treatment. Methods Eighty seven people with 1-3 brain metastases were enrolled on this Phase II trial of WBRT (30Gy/10)+simultaneous FSRT, (60Gy/10). Results Mean (Min-Max) baseline KPS, Mini Mental Status Exam (MMSE) and FACT-BR quality of life were 83 (70-100), 28 (21-30) and 143 (98-153). Lower baseline MMSE (but not KPS or FACT-Br) was associated with worse survival after adjusting for age, number of metastases, primary and extra-cranial disease status. Crude rates of deterioration (>10 points decrease from baseline for KPS and FACT-Br, MMSE fall to<27) ranged from 26-38% for KPS, 32-59% for FACT-Br and 0-16%for MMSE depending on the time-point assessed with higher rates generally noted at earlier time points (<6months post-treatment). Using a linear mixed models analysis, significant declines from baseline were noted for KPS and FACT-Br (largest effects at 6 weeks to 3 months) with no significant change in MMSE. Conclusions The effects on function and quality of life of this integrated treatment of WBRT+simultaneous FSRT were similar to other published series combining WBRT+SRS.

Type
Poster Viewing Sessions
Copyright
Copyright © The Canadian Journal of Neurological Sciences Inc. 2016 
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PS1 -125 Assessment of Function and Quality of Life in a Phase II Multi-Institutional Clinical Trial of Fractionated Simultaneous In-Field Boost Radiotherapy for Patients with 1-2 Brain Metastases
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PS1 -125 Assessment of Function and Quality of Life in a Phase II Multi-Institutional Clinical Trial of Fractionated Simultaneous In-Field Boost Radiotherapy for Patients with 1-2 Brain Metastases
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