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PET, CT, and MRI Imaging of Neuronal Migration Anomalies in Epileptic Patients

Published online by Cambridge University Press:  18 September 2015

John Falconer ,
Juhn A. Wada ,
Wayne Martin  and
David Li
John Falconer*
Affiliation:
Division of Neurosciences, Health Sciences Center Hospital, University of British Columbia, Vancouver
Juhn A. Wada
Affiliation:
Division of Neurosciences, Health Sciences Center Hospital, University of British Columbia, Vancouver
Wayne Martin
Affiliation:
Division of Neurology, Health Sciences Center Hospital, University of British Columbia, Vancouver
David Li
Affiliation:
Department of Radiology, Health Sciences Center Hospital, University of British Columbia, Vancouver
*
10510 - Hollymount Drive, Richmond, British Columbia, Canada V7E 4Z2
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Abstract:

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During the investigation of intractable epilepsy, neuronal migration anomalies [NMA] were discovered in three patients. The first patient had abnormally positioned gray matter within the walls of both lateral ventricles. The second patient had a post operative cystic area in the right parietal-occipital lobes and an area of NMA within the right temporal lobe. The third patient had abnormally thickened gray matter in the right operculum. Long term CCTV-EEG monitoring of these three patients revealed ictal discharges originating from the area of abnormal gray matter in patients 2 and 3. PET scanning showed the areas of NMA in all three patients to have similar metabolic activity to normal gray matter. These cases illustrate the value of various imaging modalities and suggest some interesting physiology of a spectrum of neuronal migration anomalies.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 1 , February 1990 , pp. 35 - 39
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

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