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Optimal Check Size and Reversal Rate to Elicit Pattern-reversal MEG Responses

Published online by Cambridge University Press:  02 December 2014

Wei-Ta Chen
Affiliation:
Neurological Institute, Taipei Veterans General Hospital, and Department of Neurology, Taipei Medical University Hospital, and School of Medicine, and Institute of Neuroscience, School of Life Science, National Yang-Ming University, Taipei, Taiwan
Yu-Chieh Ko
Affiliation:
Department of Ophthalmology, Taipei Veterans General Hospital, and Institute of Clinical Medicine, and School of Medicine, National Yang-Ming University, Taipei, Taiwan
Kwong-Kum Liao
Affiliation:
Neurological Institute, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University, Taipei, Taiwan
Jen-Chuen Hsieh
Affiliation:
Department of Medical Research and Education, Taipei Veterans General Hospital, and School of Medicine, and Institute of Neuroscience, School of Life Science, National Yang-Ming University, Taipei, Taiwan
Tzu-Chen Yeh
Affiliation:
Department of Medical Research and Education, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University, Taipei, Taiwan
Zin-An Wu
Affiliation:
Neurological Institute, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University, Taipei, Taiwan
Low-Tone Ho
Affiliation:
Department of Medical Research and Education, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University, Taipei, Taiwan
Yung-Yang Lin
Affiliation:
Neurological Institute, and Department of Medical Research and Education, Taipei Veterans General Hospital, and School of Medicine, and Institute of Neuroscience, School of Life Science, National Yang-Ming University, Taipei, Taiwan
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Abstract:

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Objective:

To determine the impact of check size and interstimulus interval (ISI) on neuromagnetic visual cortical responses.

Methods:

We recorded visual evoked fields to pattern-reversal stimulation with central occlusion in ten subjects. The ~100 ms magnetic activation (P100m) was analyzed by single dipole modeling.

Results:

With 1 s ISI, P100m strengths increased as check size increased from 15' up to 120' of visual arc, and larger checks elicited less P100m activation. With 120' checks, we found no P100m attenuation as ISI decreased from 4 s to 0.16 s. P100m sources around the calcarine sulcus did not vary with check size or ISI.

Conclusions:

The magnitude of cortical activation during visual contrast processing is check size-dependent and the 120' checks are optimum for future studies on neuromagnetic visual cortical functions using central-occluded stimulation. The corresponding neuronal activation demonstrated a short refractory period less than 0.16 s. We also found significantly overlapping cortical representation areas for different check sizes or ISIs.

Résumé:

RÉSUMÉ:Objectif:

Déterminer l’impact de la taille des carreaux et de l’intervalle inter stimulus (IIS) sur les réponses corticales visuelles neuromagnétiques.

Méthodes:

Nous avons enregistré des potentiels évoqués visuels à la stimulation par damier avec occlusion centrale chez 10 sujets. L’activation magnétique ~100 ms (P100m) a été analysée par modélisation dipôle unique.

Résultats:

Avec 1 s d’IIS, les forces P100m augmentaient avec l’augmentation de la taille des carreaux de 15' jusqu’à 120' d’arc visuel. Les carreaux de plus grande taille déclenchaient moins d’activation P100m. Avec des carreaux de 120', nous n’avons observé aucune attenuation P100m avec la diminution d’IIS de 4 s à 0,16 s. Les sources P100m autour de la scissure calcarine ne variaient pas selon la taille des carreaux ou l’IIS.

Conclusions:

L’ampleur de l’activation corticale pendant le traitement du contraste visuel est dépendant de la taille des carreaux et les carreaux de 120' sont optimaux pour l’étude des fonctions corticales visuelles neuromagnétiques utilisant l’occlusion centrale. L’activation neuronale correspondante a une période réfractaire courte de moins de 0,16 s. Nous avons également constaté un chevauchement significatif des zones de représentation corticale pour des carreaux de tailles différentes ou des IISs différents.

Type
Original Articles
Copyright
Copyright © The Canadian Journal of Neurological 2005

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