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Myopathy Associateci with Amyloid Angiopathy

Published online by Cambridge University Press:  03 July 2018

Joseph Bruni ,
Juan M. Bilbao  and
Kenneth P. H. Pritzker
Joseph Bruni
Affiliation:
Departments of Pathology, St. Michael’s Hospital and Mount Sinai Hospital, University of Toronto, Ontario, Canada
Juan M. Bilbao*
Affiliation:
Departments of Pathology, St. Michael’s Hospital and Mount Sinai Hospital, University of Toronto, Ontario, Canada
Kenneth P. H. Pritzker
Affiliation:
Departments of Pathology, St. Michael’s Hospital and Mount Sinai Hospital, University of Toronto, Ontario, Canada
*
Department of Pathology, St. Michael’s Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8.
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Summary

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A 38-year-old patient with the clinical picture of a progressive myopathy resembling limb girdle muscular dystrophy is presented. Muscle biopsy showed amyloid deposits in the walls of small endomysial blood vessels. There was no clinical or physiological evidence of peripheral nerve involvement, no plasma cell dyscrasia and no generalized amyloidosis. There was no muscle fiber hypertrophy, inflammation or neurogenic change. There was no response to steroid therapy.

The etiopathogenesis of this amyloid angiopathy is undetermined. The extensive vessel involvement with amyloid deposition and the absence of changes indicative of muscular dystrophy or inflammatory myopathy leads us to favor an ischemic basis for this patient’s myopathy.

Résumé

Résumé

Le cas d'un patient de 38 ans avec une myopathie progressive ressemblant á une dystrophie des ceintures est présenté. Une biopsie du muscle montra des dépôts amyloϊdiens sur les parois de petits vaisseaux sanguins de I'endomètre. II n'y avail pas d' évidence clinique ou physiologique d'atteinte du nerf périphérique, pas de dyscrasie des cellules plasmatiques et pas d'amyloϊdose généralisée. II n'y avail pas d'hypertrophie des fibres musculaires, ni d'inflammation ou de changement neurogenique. II n'y eut pas de reponse au traitement aux stéroϊdes.

L'étiopathogénèse de cette angiopathie amyloϊde n'est pas déterminée. L'implication du vaisseau avec depot amyloϊde et I'absence de changements indicatifs d'une dystrophie musculaire ou d'une myopathie inflammatoire nous améne á croire en une raison ischèmique pour la myopathie de ce patient.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 4 , Issue 1 , February 1977 , pp. 77 - 80
Copyright
Copyright © Canadian Neurological Sciences Federation 1977

References

Bradley, W. G., O’Brien, M. D., Walder, D. N., Murchison, D., Johnson, M., and Newell, D. (1975). Failure to confirm a vascular cause of muscular dystrophy Archives of Neurology, 32, 466–474.Google Scholar
Brown, H. D., Chattpadhyay, S. K., and Patel, A. B. (1967). Erythrocyte abnormality in human myopathy. Science, 157, 1577–1578.Google Scholar
Cazzato, G. (1968). Considerations about a possible role played by connective tissue proliferation and vascular disturbances in the pathogenesis of progressive muscular dystrophy European Neurology, 1, 158–179.CrossRefGoogle ScholarPubMed
Demos, J. (1961). Mesure des temps de circulation chez 79 myopathies. Revue Francaise d’Etudes Cliniques et Biologiques, 6, 876–887.Google Scholar
Engel, W. K. (1973). Duchenne muscular dystrophy: A histologically based ischemia hypothesis and comparison with experimental ischemia myopathy, in Pearson, C. M., Mostofi, F- K. (eds): Academy of Paiftology Monograph. Baltimore, Williams and Wilkins Co., pp. 453–472.Google Scholar
Harriman, D. G. F. (1976). Muscle, in Blackwood, W., Corsellis, A. N. (ed): Greenfield’s Neuropathology, London, Edward Arnold Ltd., pp. 849–902.Google Scholar
Hathway, P. W., Engel, W. K., and Zellweger, H. (1970). Experimental myopathy after micro arterial embolization. Comparison with childhood X-linked pseudo-hypertrophic muscular dystrophy Archives of Neurology, 22, 365–378.Google Scholar
Karpati, G., Carpenter, S., Melmud, C. and Eisen, A. (1974). Experimental ischemic myopathy Journal of the Neurological Sciences, 23, 129–161.Google Scholar
Lumb, E. M., and Emery, A. E. H. (1975). Erythrocyte deformation in Duchenne muscular dystrophy. British Medical Journal, 2, 467–468.CrossRefGoogle Scholar
Martin, J. J., Vanbogaert, L., Van Damme, J., and Peremans, J. (1970). Sur une pseudo-myopathie ligneuse generalisee par amyloidose primaire endomysio-vasculaire. Journal of the Neurological Sciences, 11, 147–166.Google Scholar
Matheson, D. W., Howland, J. L. (1974). Erythrocyte deformation in human muscular dystrophy. Science, 184, 165–166.Google Scholar
Mawatari, S., Schonberg, M., Olarte, M. (1976). ATPase and adenyl cyclase in erythrocytes of patients with Duchenne muscular dystrophy. Archives of Neurology, 489–493.CrossRefGoogle Scholar
McComas, A. J., Sica, R. E. P., Campbell, M. J. (1971). “Sick” motoneurones: A unifying concept of muscle disease. Lancet, 1, 321–325.Google Scholar
McComas, A. J., Sica, R. E. P., and Upton, A. R. M. (1974). Multiple muscle analysis of motor units in muscular dystrophy. Archives of Neurology, 30, 249–251.CrossRefGoogle ScholarPubMed
Miller, S. E., Roses, A. D., and Appel, S. H. (1975). Erythrocytes in human muscular dystrophy. Science, 188, 1131.Google Scholar
Paulson, O. B., Engel, A. G., Gomez, M. R. (1974). Muscle blood flow in Duchenne type muscular dystrophy, limb-girdle dystrophy, polymyositis, and in normal controls. Journal of Neurology, Neurosurgery and Psychiatry, 37, 685–690.CrossRefGoogle ScholarPubMed
Reichenmiller, H. E., Bundschu, H. D., Bass, L., Missmahl, H. P., Arnold, M. (1968). Progressive muscular dystrophy and pericollagenous amyloidosis. German Medical Monthly, 13, 380–384.Google ScholarPubMed
Rowland, L. P. (1976). Pathogenesis of muscular dystrophies. Archives of Neurology, 33, 315–321.CrossRefGoogle ScholarPubMed
Sha’afi, R. I., Rodan, S. B., Hintz, R. L., Fernandes, S. M., and Rodan, G. A. (1975). Abnormalities in membrane microviscosity and ion transport in genetic muscular dystrophy. Nature, 254, 525–526.Google Scholar