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Myasthenia Gravis in a Child with Sequelae of Opsoclonus-Myoclonus Syndrome

Published online by Cambridge University Press:  18 September 2015

Angus A. Wilfong  and
Fabio Fernandez
Angus A. Wilfong*
Affiliation:
Departments of Pediatrics and Neurology, Baylor College of Medicine, Houston, Texas
Fabio Fernandez*
Affiliation:
Departments of Pediatrics and Neurology, Baylor College of Medicine, Houston, Texas
*
Section of Pediatric Neurology, Room R-618, Texas Children’s Hospital, 6621 Fannin, Houston, Texas, U.S.A. 77030
Section of Pediatric Neurology, Room R-618, Texas Children’s Hospital, 6621 Fannin, Houston, Texas, U.S.A. 77030
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Abstract:

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Immune-mediated myasthenia gravis occurred in a 13-month-old girl who had sequelae of an opsoclonus-myoclonus syndrome. She had an abnormal Raji cell assay along with elevated antiacetylcholine receptor and antithyroglobulin antibodies. No evidence of an associated malignancy was found with either condition. Clearly, the co-occurrence of two diseases within a single patient does not establish a common pathogenesis. Nevertheless, this is a provocative association and may point to an immunologically mediated process in the opsoclonus-myoclonus syndrome.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 1 , February 1992 , pp. 88 - 89
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

References

1. Orzechowski, K.De l’ataxie dysmetrique des yeux: remarques sur l’ataxie des yeux myoclonique (Opsoclonie, Opsochorie). J Psychol Neurol 1927; 35: 1–18.Google Scholar
2. Kinsbourne, M.Myoclonic encephalopathy of infants. J Neurol Neurosurg Psychiatry 1962; 25: 271–276.CrossRefGoogle ScholarPubMed
3. Warrier, RP, Kini, R, Besser, A, et al. Opsomyoclonus and Neuroblastoma. Clin Pediatr 1985; 24: 32–34.Google ScholarPubMed
4. Digre, KB.Opsoclonus in Adults. Report of Three Cases and Review of the Literature. Arch Neurol 1986; 43: 1165–1175.CrossRefGoogle ScholarPubMed
5. Dyken, P, Kolar, O.Dancing Eyes, Dancing Feet: Infantile Polymyoclonia. Brain 1968; 91: 305–320.CrossRefGoogle ScholarPubMed
6. Bray, PF, Ziter, FA, Lahey, ME, et al. The Coincidence of Neuroblastoma and Acute Cerebellar Encephalopathy. J Pediatr 1969; 75: 983–990.CrossRefGoogle ScholarPubMed
7. Dropcho, EJ.The Remote Effects of Cancer on the Nervous System. Neurol Clin 1989; 7: 579–603.CrossRefGoogle ScholarPubMed
8. Plioplys, AV, Greaves, A, Yoshida, W.Anti-CNS Antibodies in Childhood Neurological Diseases. Neuropediatrics 1989; 20: 93–102.Google Scholar
9. Steinman, L.Immunogenetic Mechanisms in Myasthenia Gravis. Prog Brain Res 1990; 84: 117–124.CrossRefGoogle ScholarPubMed
10. Vincent, A.Neuroimmunology of Myasthenia Gravis. Brain Behav Immunol 1988; 2: 346–351.CrossRefGoogle ScholarPubMed