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Meta-Analysis on the Association Between the TF Gene rs1049296 and AD

Published online by Cambridge University Press:  23 September 2014

Yun Wang
Affiliation:
Department of Neurology, The Second Hospital of Shandong University, Jinan, PR China
Shunliang Xu
Affiliation:
Department of Neurology, The Second Hospital of Shandong University, Jinan, PR China
Zhen Liu
Affiliation:
Department of Neurology, The Second Hospital of Shandong University, Jinan, PR China
Chao Lai
Affiliation:
Department of Neurology, The Second Hospital of Shandong University, Jinan, PR China
Zhaohong Xie
Affiliation:
Department of Neurology, The Second Hospital of Shandong University, Jinan, PR China
Cuiping Zhao
Affiliation:
Department of Neurology, The Second Hospital of Shandong University, Jinan, PR China
Yan Wei
Affiliation:
Department of Neurology, The Second Hospital of Shandong University, Jinan, PR China
Jian Zhong Bi*
Affiliation:
Department of Neurology, The Second Hospital of Shandong University, Jinan, PR China
*
Department of Neurology, the second hospital of Shandong University, Jinan 250033, China. Email: bjz@sdu.edu.cn
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Abstract:

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Background:

Polymorphisms of genes participating in iron transportation have been associated with Alzheimer's disease (AD) risk. The association between transferrin (TF) gene rs1049296 (P570S) polymorphism and AD is controversial.

Methods:

We performed meta analysis on data from 19 studies with 6310 cases and 13661 controls to reexamine the association between the TF gene rs1049296 polymorphism and AD. We applied a fixed-effects model to combine the odds ratio (OR) and 95% confidence intervals (95% CI). Egger's test was carried out to evaluate the potential publication bias.

Results:

The overall ORs with 95% CIs showed statistical association between the TF gene rs1049296 polymorphism and the risk of AD in the allele contrast, the recessive model and the dominant model for allele C2 (fixed-effects pooled OR 1.11; 95% CI 1.05 to 1.17, pooled OR 1.13; 95% CI 1.06 to 1.21, and pooled OR 1.23; 95% CI 1.03 to 1.47, respectively). In the contrast of C2C2+C2C1 vs C1C1, large heterogeneity among the Asian subgroup (p=0.041, I2= 68.6%) was observed but not among the overall population (p = 0.184, I2= 22.4%). No publication bias was observed.

Conclusions:

The present meta analysis demonstrated that TF gene rs1049296 polymorphism is a genetic determinant of AD.

Type
Original Article
Copyright
Copyright © The Canadian Journal of Neurological 2013

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