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Glioblastoma: If this is the “Temozolomide Era” Where is the Evidence?

Published online by Cambridge University Press:  23 September 2014

James R. Perry*
Affiliation:
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
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Abstract

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Type
Editorial
Copyright
Copyright © The Canadian Journal of Neurological 2014

References

1.Brain Tumour Foundation of Canada website. [cited 2014 Jan 28]. Available from: http://www.braintumour.ca/2494/brain-tumour-facts.Google Scholar
2.Coate, L, McNamara, MG, Lwin, Z. Glioblastoma treatment in the elderly in the temozolomide therapy era. Can J Neurol Sci. 2014 41(3)35762.Google Scholar
3.Laperriere, N, Weller, M, Stupp, R. Optimal management of elderly patients with glioblastoma. Cancer Treat Rev. 2013 39 3507.CrossRefGoogle ScholarPubMed
4.Perry, JR, Callaghan, C O, Ding, K. A phase III randomized controlled trial of short-course radiotherapy with or without concomitant and adjuvant temozolomide in elderly patients with glioblastoma (NCIC CTG CE.6, EORTC 26062–22061, TROG 08.02). Can J Neuro Sci. 2012 Jan39 Suppl 1S16 .Google Scholar
5.Cao, JQ, Fisher, BJ, Bauman, GS, Megyesi, JF, Watling, CJ, Macdonald, DR. Hypofractionated radiotherapy with or without concurrent temozolomide in elderly patients with glioblastoma multiforme: a review of ten-year single institutional experience. J Neurooncol. 2012 107 395405.Google Scholar
6.Sanghera, P, Perry, JR, Sahgal, A. Pseudoprogression following chemoradiotherapy for glioblastoma multiforme. Can J Neurol Sci. 2010 37 3642.Google Scholar
7.Malmström, A, Gronberg, BH, Marosi, C. Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomized, phase 3 trial. Lancet Oncol. 2012 13(9)91626.Google Scholar
8.Wick, W, Platten, M, Meisner, C. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomized, phase 3 trial. Lancet Oncol. 2012 13(7)70715.Google Scholar