Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2025-01-02T19:52:55.340Z Has data issue: false hasContentIssue false
  • English
  • Français

Functional Impairment in Patients with Sporadic Inclusion Body Myositis

Published online by Cambridge University Press:  23 September 2014

Heather V. Dunlap ,
Lauren G. MacNeil  and
Mark A. Tarnopolsky
Heather V. Dunlap
Affiliation:
Departments of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Lauren G. MacNeil
Affiliation:
Departments of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Mark A. Tarnopolsky
Affiliation:
Departments of Pediatrics, McMaster University, Hamilton, Ontario, Canada Medicine, McMaster University, Hamilton, Ontario, Canada
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction:

We conducted a retrospective chart review of 53 patients diagnosed with sporadic Inclusion Body Myositis (sIBM) who have been followed at the McMaster Neuromuscular Clinic since 1996.

Objectives:

We reviewed patient medical histories in order to compare our findings with similar cohorts, and analyzed quantitative strength data to determine functionality in guiding decisions related to gait assistive devices.

Methods:

Patient information was acquired through retrospective clinic chart review.

Results:

Our study found knee extension strength decreased significantly as patients transitioned to using more supportive gait assistive devices (P < 0.05). A decline to below 30 Nm was particularly indicative of the need for a preliminary device (i.e. cane)(P < 0.05). Falls and fear of falling poses a significant threat to patient physical well-being. The prevalence of dysphagia increased as patients required more supportive gait devices, and finally a significant negative correlation was found between time after onset and creatine kinase (CK) levels (P < 0.01).

Conclusion:

This study supports that knee extension strength may be a useful tool in advising patients concerning ambulatory assistance. Further investigations concerning gait assistive device use and patient history of falling would be beneficial in preventing future falls and improving long-term patient outcomes.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 41 , Issue 2 , March 2014 , pp. 253 - 259
Copyright
Copyright © The Canadian Journal of Neurological 2014

References

1.Chou, SM.Myxovirus-like structures and accompanying nuclear changes in chronic polymyositis. Arch Pathol. 1968;86(6):649–58.Google Scholar
2.Dimachkie, MM, Barohn, RJ.Inclusion body myositis. Semin Neurol. 2012;32(3):237–45.Google Scholar
3.Needham, M, Mastaglia, FL.Inclusion body myositis: current pathogenic concepts and diagnostic and therapeutic approaches. Lancet Neurol. 2007;6:620–31.Google Scholar
4.Griggs, RC, Askanas, V, DiMauro, S, et al. Inclusion body myositis and myopathies. Ann Neurol. 1995;38(5):705–13.Google Scholar
5.Dalakas, MC.Sporadic body myositis – diagnosis, pathogenesis and therapeutic strategies. Nat Clin Pract Neurol. 2006;2(8):437–47.CrossRefGoogle ScholarPubMed
6.Cox, FM, Verschuuren, JJ, Verbist, BM, Niks, EH, Wintzen, AR, Badrising, UA.Detecting dysphagia in inclusion body myositis. J Neurol. 2009;256(12):2009–13.Google Scholar
7.de Merieux, P, Verity, MA, Clements, PJ, Paulus, HE.Esophageal abnormalities and dysphagia in polymyositis and dermatomyositis. Arthritis Rhem. 1983;26(8):961–8.Google Scholar
8.Houser, SM, Calabrese, LH, Strome, MS.Dysphagia in patients with inclusion body myositis. Laryngoscope. 1998;108(7):1001–5.Google Scholar
9.Garlepp, MJ, Mastaglia, FL.Inclusion body myositis. J Neurol Neurosurg Psychiatry. 1996;60(3):251–5.CrossRefGoogle ScholarPubMed
10.Dalakas, MC, Sonies, B, Dambrosia, J, Sekul, E, Cupler, E, Sivakumar, K.Treatment of inclusion body myositis with IVIg: a double-blind, placebo-controlled study. Neurology. 1997;48(3):712–16.Google Scholar
11.Lotz, BP, Engel, AG, Nishino, H, Stevens, JC, Litchy, WJ.Inclusion body myositis observations in 40 patients. Brain. 1988;112(3):727–47.Google Scholar
12.Aggarwal, R, Oddis, CV.Therapeutic approaches in myositis. Curr Rhematol Rep. 2011;13(3):182–91.Google Scholar
13.Dimachkie, MM, Barohn, RJ.Inclusion body myositis. Curr Neurol Neurosci Rep. 2013;13:321.Google Scholar
14.Bernhardt, KA, TH, Oh, Kaufman, KR.Gait patterns of patients with inclusion body myositis. Gait Posture. 2011;33(3):442–6.Google Scholar
15.Cox, FM, Titulaer, MJ, Sont, JK, et al. A 12-year follow-up in sporadic inclusion body myositis: an end stage with major disabilities. Brain. 2011;134(Pt 11):3167–75.Google Scholar
16.Jackson, CE, Barohn, RJ, Gronseth, G, Pandya, S, Herbelin, L.Inclusion body myositis functional rating scale: a reliable and valid measure of disease severity. Muscle Nerve. 2008;37(4):473–6.Google Scholar
17.Benveniste, O, Guiguet, M, Freebody, J, et al. Long-term observational study of sporadic inclusion body myositis. Brain. 2011;134(Pt 11):3176–84.Google Scholar
18.Tarnopolsky, M, Zimmer, A, Paikin, J, et al. Creatine monohydrate and conjugated linoleic acid improves strength composition following resistance exercise in older adults. PLoS One. 2007;2(10):e991.CrossRefGoogle ScholarPubMed
19.Tarnopolsky, M, Phillips, S, Parise, G, et al. Gene expression, fiber type, and strength are similar between left and right legs in older adults. J Gerontol A Biol Sci Med Sci. 2007;62(10):1088–95.Google Scholar
20.Crane, JD, Macneil, LG, Tarnopolsky, MA.Long-term aerobic exercise is associated with greater muscle strength throughout the life span. J Gerontol A Biol Sci Med Sci. 2013;68(6):631–8.Google Scholar
21.Lowes, LP, Alfano, L, Viollet, L, et al. Knee extensor strength exhibits potential to predict function in sporadic inclusion-body myositis. Muscle Nerve. 2012;45(2):163–8.CrossRefGoogle ScholarPubMed
22.Badrising, UA, Maat-Schieman, M, van Duinen, SG, et al. Epidemiology of inclusion body myositis in the Netherlands: a nationwide study. Neurology. 2000;55(9):1385–7.Google Scholar
23.Ehlers, GG, Ball, TE, Liston, L.Creatine kinase levels are elevated during 2-A-Day practices in collegiate football players. J Athl Train. 2002;37(2):151–6.Google ScholarPubMed
24.Amato, AA, Gronseth, GS, Jackson, CE, et al. Inclusion body myositis: clinical and pathological boundaries. Ann Neurol. 1996;40(4):581–6.Google Scholar
25.Phillips, BA, Cala, LA, Thickbroom, GW, Melsom, A, Zilko, PJ, Mastaglia, FL.Patterns of muscle involvement in inclusion body myositis: clinical and magnetic resonance imaging study. Muscle Nerve. 2001;24(11):1526–34.Google Scholar
26.Massy-Westropp, NM, Gill, TK, Taylor, AW, Bohannon, RW, Hill, CL.Hand grip strength: age and gender stratified normative data in a population-based study. BMC Res Notes. 2011;4:127.Google Scholar
27.Borges, O.Isometric and isokinetic knee extension and flexor torque in men and women aged 20–70. Scand J Rehabil Med. 1989;21(1):45–53.Google Scholar
28.Jubrias, SA, Odderson, IR, Esselman, PC, Conley, KE.Decline in isokinetic force with age: muscle cross-section area and specific force. Eur J Physiol. 1997;434(3):246–53.Google Scholar
29.Tarnopolsky, MA, Mahoney, DJ, Vajsar, J, et al. Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy. Neurology. 2004;62(10):1771–7.Google Scholar
30.Feiring, DC, Ellenbecker, TS, Derscheid, GL.Test-rest reliability of the biodex isokinetic dynamometer. J Orthop Sports Phys Ther. 1990;11(7):298–300.Google Scholar
31.Legters, K.Fear of falling. Phys Ther. 2002;82(3):264–72.Google Scholar
32.Badrising, UA, Maat-Schieman, MLC, van Houwelingen, JC, et al. Inclusion body myositis. Clinical features and clinical course of the disease in 64 patients. J Neurol. 2005;252(12):1448–54.CrossRefGoogle ScholarPubMed
33.Newell, AM, VanSwearingen, JM, Hile, E, Brach, JS.The modified gait efficiency scale: establishing the psychometric properties in older adults. Phys Ther. 2012;92(2):318–28.Google Scholar