Skip to main content Accessibility help
×
Home
Hostname: page-component-78bd46657c-lkdxh Total loading time: 0.305 Render date: 2021-05-08T06:57:36.042Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": false, "newCiteModal": false, "newCitedByModal": true }

Frontal Assessment Battery to Evaluate Frontal Lobe Dysfunction in ALS Patients

Published online by Cambridge University Press:  02 December 2014

Suk-Won Ahn
Affiliation:
Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine
Su-Hyun Kim
Affiliation:
Department of Neurology, Seoul National University Hospital Department of Neurology, Hanyang University College of Medicine, Seoul, Republic of Korea
Jee-Eun Kim
Affiliation:
Department of Neurology, Seoul National University Hospital
Sung-Min Kim
Affiliation:
Department of Neurology, Seoul National University Hospital
Seung Hyun Kim
Affiliation:
Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine
Jung-Joon Sung
Affiliation:
Department of Neurology, Seoul National University Hospital
Kwang-Woo Lee
Affiliation:
Department of Neurology, Seoul National University Hospital
Yoon-Ho Hong
Affiliation:
Department of Neurology, Boramae Medical Center, Seoul National University College of Medicine
Rights & Permissions[Opens in a new window]

Abstract

Background:

Assessment of frontal lobe impairment in amyotrophic lateral sclerosis (ALS) is a matter of great importance, since it often causes ALS patients to decrease medication and nursing compliance, thus shortening their survival time.

Methods:

The frontal assessment battery (FAB) is a short and rapid method for assessing frontal executive functions. We investigated the applicability of the FAB as a screening method for assessing cognitive impairments in 61 ALS patients. Depending on the results of the FAB, we classified patients into two subgroups: FAB-normal and FAB-abnormal. We then performed additional evaluations of cognitive function using the Korean version of the mini-mental state examination (K-MMSE), a verbal fluency test (COWAT), and a neuropsychiatric inventory (NPI). Results of these tests were compared between the two groups using Mann-Whitney U-tests, and Spearman correlation analyses were used to investigate the relationships between FAB score and disease duration and severity.

Results:

Of the 61 sporadic ALS patients included in this study, 14 were classified as FAB-abnormal and 47 were classified as FAB-normal. The FAB-normal and FAB-abnormal patients performed significantly differently in all domains of the COWAT. There was no difference in behavioral disturbance, as assessed by the NPI, between the two groups. The FAB scores were found to significantly correlate with both disease duration and severity.

Conclusions:

The FAB shows promise as a method of screening for frontal lobe dysfunction in ALS, as it is not only quick and easy, but also reliable. Additional studies should examine how FAB performance changes as ALS progresses.

Type
Original Article
Copyright
Copyright © The Canadian Journal of Neurological 2011

References

1Ringholz, GM, Appel, SH, Bradshaw, M, Cooke, NA, Mosnik, DM, Schulz, PE.Prevalence and patterns of cognitive impairment in sporadic ALS. Neurology. 2005;65:58690.CrossRefGoogle ScholarPubMed
2Murphy, JM, Henry, RG, Langmore, S, Kramer, JH, Miller, BL, Lomen-Hoerth, C.Continuum of frontal lobe impairment in amyotrophic lateral sclerosis. Arch Neurol. 2007;64:5304.CrossRefGoogle ScholarPubMed
3Strong, MJ, Grace, GM, Freedman, M, et al.Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2009;10:13146.CrossRefGoogle Scholar
4Olney, RK, Murphy, J, Forshew, D, et al.The effects of executive and behavioral dysfunction on the course of ALS. Neurology. 2005; 65:17747.CrossRefGoogle ScholarPubMed
5Dubois, B, Slachevsky, A, Litvan, I, Pillon, B.The FAB: a Frontal Assessment Battery at bedside. Neurology. 2000;50:16216.CrossRefGoogle Scholar
6Appollonio, I, Leone, M, Isella, V, et al.The Frontal Assessment Battery (FAB): normative values in an Italian population sample. Neurol Sci. 2005;26:10816.CrossRefGoogle Scholar
7Lima, CF, Meireles, LP, Fonseca, R, Castro, SL, Garrett, C.The Frontal Assessment Battery (FAB) in Parkinson’s disease and correlations with formal measures of executive functioning. J Neurol. 2008;255:175661.CrossRefGoogle ScholarPubMed
8Slachevsky, A, Villalpando, JM, Sarazin, M, Hahn-Barma, V, Pillon, B, Dubois, B.Frontal assessment battery and differential diagnosis of frontotemporal dementia and Alzheimer disease. Arch Neurol. 2004;61:11047.CrossRefGoogle ScholarPubMed
9Brooks, BR, Miller, RG, Swash, M, Munsat, TL.World Federation of Neurology Research Group on Motor Neuron Disease. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2000;1: 2938.Google Scholar
10Cedarbaum, JM, Stambler, N, Malta, E, et al.The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci. 1999;169:1321.CrossRefGoogle Scholar
11Rodriguez-Aranda, C, Martinussen, M.Age-related differences in performance of phonemic verbal fluency measured by Controlled Oral Word Association Task (COWAT): a meta-analytic study. Dev Neuropsychol. 2006;30:697717.CrossRefGoogle ScholarPubMed
12Lee, BR, Chun, JE, Lee, SJ, Lee, BH, Yu, IK, Kim, SY.Cognitive dysfunction in 16 Patients with carotid stenosis: detailed neuropsychological findings. J Clin Neurol. 2007;3:917.Google Scholar
13Han, C, Jo, SA, Jo, I, Kim, E, Park, MH, Kang, Y.An adaptation of the Korean mini-mental state examination (K-MMSE) in elderly Koreans: demographic influence and population-based norms (the AGE study). Arch Gerontol Geriatr. 2008;47:30210.CrossRefGoogle Scholar
14Blair, M, Kertesz, A, Davis-Faroque, N, et al.Behavioral measures in frontotemporal lobar dementia and other dementias: the utility of the frontal behavioural inventory and the neuropsychiatric inventory in a national cohort study. Dement Geriatr Cogn Disord. 2007;23:40615.CrossRefGoogle Scholar
15Kim, TH, Huh, Y, Choe, JY, et al.Korean version of frontal assessment battery: psychometric properties and normative data. Dement Geriatr Cogn Disord. 2010;29:36370.CrossRefGoogle ScholarPubMed
16Guedj, E, Allali, G, Goetz, C, et al.Frontal Assessment Battery is a marker of dorsolateral and medial frontal functions: a SPECT study in frontotemporal dementia. J Neurol Sci. 2008;273:847.CrossRefGoogle ScholarPubMed
17Warburton, E, Wise, RJ, Price, CJ, et al.Noun and Verb retrieval by normal subjects. Study with PET. Brain. 1996;119:15979.Google ScholarPubMed
18Konish, S, Nakajima, K, Uchida, I, Kikyo, H, Kameyama, M, Miyashita, Y.Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI. Brain. 1999;122:98191.CrossRefGoogle Scholar
19Elman, LB, Grossman, M.Neuropsychiatric features of amyotrophic lateral sclerosis. Neuro Rehab. 2007;22:4259.Google ScholarPubMed
20Oskarsson, B, Quan, D, Rollins, YD, Neville, HE, Ringel, SP, Arciniegas, DB.Using the Frontal Assessment Battery to identify executive function impairments in amyotrophic lateral sclerosis: a preliminary experience. Amyotroph Lateral Scler. 2010;11:2447.CrossRefGoogle ScholarPubMed
You have Access

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Frontal Assessment Battery to Evaluate Frontal Lobe Dysfunction in ALS Patients
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Frontal Assessment Battery to Evaluate Frontal Lobe Dysfunction in ALS Patients
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Frontal Assessment Battery to Evaluate Frontal Lobe Dysfunction in ALS Patients
Available formats
×
×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *