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Familial Benign Intracranial Hypertension and Depression

Published online by Cambridge University Press:  18 September 2015

C. Edward Coffey*
Affiliation:
Departments of Neurology and Psychiatry, Duke University Medical Center, Durham, N.C. 27710
Donald R. Ross
Affiliation:
Departments of Neurology and Psychiatry, Duke University Medical Center, Durham, N.C. 27710
E. Wayne Massey
Affiliation:
Departments of Neurology and Psychiatry, Duke University Medical Center, Durham, N.C. 27710
C. Warren Olanow
Affiliation:
Departments of Neurology and Psychiatry, Duke University Medical Center, Durham, N.C. 27710
*
Box 31090, Duke University Medical Center, Durham, N.C. 27710, 919-684-8111
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Summary:

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Two sisters developed benign intracranial hypertension (BIH) two weeks following the resolution of a major depressive episode. The association of BIH and a major affective disorder in genetically related individuals has not been previously reported to our knowledge. Both conditions are associated with disturbances in the hypothalamic-pituitary-adrenal axis. Falling corticosteroid levels in a resolving depression may result in impaired cerebrospinal fluid absorption and subsequent BIH.

Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

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