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Environmental Factors in the Etiology of Parkinson's Disease

Published online by Cambridge University Press:  05 January 2016

Caroline M. Tanner*
Affiliation:
Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
Biao Chen
Affiliation:
Department of Neurology, Sun Yat Sen Medical University, Guongzhou, China
Wen-Zhi Wang
Affiliation:
Beijing Neurosurgical Institute, Beijing, China
Man-Ling Peng
Affiliation:
Beijing Neurosurgical Institute, Beijing, China
Zho-Lin Liu
Affiliation:
Department of Neurology, Sun Yat Sen Medical University, Guongzhou, China
Xue-Ling Liang
Affiliation:
Department of Neurology, Sun Yat Sen Medical University, Guongzhou, China
Li Chiung Kao
Affiliation:
Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
David W. Gilley
Affiliation:
Department of Psychology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
Bruce S. Schoenberg
Affiliation:
Neuroepidemiology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
*
Department of Clinical Neurological Sciences, University Hospital, Saskatoon, Saskatchewan, Canada S7N 0X0
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Abstract:

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Parkinson's disease (PD) has been proposed to result from the interaction of aging and environment in susceptible individuals. Defective metabolism of debrisoquine, inherited as an autosomal recessive, has been associated with this susceptibility. In 35 PD patients and 19 age-matched controls, no significant differences in debrisoquine metabolism were found, although a trend to impaired metabolism was noted in patients with disease onset ≤40. Foci of PD patients were associated with rural living and well water drinking, or rural living coupled with market gardening or wood pulp mills. In a questionnaire survey, patients with PD onset ≤age 47 were significantly more likely to have lived in rural areas and to have drunk well water than those with onset ≥age 54 (p≤0.01). Because of population mobility in North America, a case-control study designed to test environmental, occupational, dietary and other proposed risk factors for PD was conducted in China, where the population is more stationary and the environment more stable. No significant differences in incidences of head trauma, smoking or childhood measles were found between patients and controls.

Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1987

References

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