Hostname: page-component-7bb8b95d7b-qxsvm Total loading time: 0 Render date: 2024-09-20T11:02:08.272Z Has data issue: false hasContentIssue false
  • English
  • Français

A Case-Control Study of Parkinson's Disease in Urban Population of Southern Israel

Published online by Cambridge University Press:  24 February 2017

Yuval O. Herishanu ,
Mordechai Medvedovski ,
John R. Goldsmith  and
Ella Kordysh
Yuval O. Herishanu*
Affiliation:
Department of Neurology, Goldman Faculty of Health Sciences, Ben Gurion University, Beer-Sheva, Israel
Mordechai Medvedovski
Affiliation:
Department of Neurology, Goldman Faculty of Health Sciences, Ben Gurion University, Beer-Sheva, Israel
John R. Goldsmith
Affiliation:
Unit of Epidemiology and Evaluation of Health Services, Goldman Faculty of Health Sciences, Ben Gurion University, Beer-Sheva, Israel
Ella Kordysh
Affiliation:
Unit of Epidemiology and Evaluation of Health Services, Goldman Faculty of Health Sciences, Ben Gurion University, Beer-Sheva, Israel
*
Department of Neurology, Soroka Medical Center, PO Box 151, Beer-Sheva, Israel.
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Background:

In recent years, an increased prevalence of Parkinson's disease (PD) in southern Israel was observed. The aim of this study was to determine which exposures are associated with PD in the urban population of this region.

Methods:

Ninety-three PD patients living in towns were compared to 93 age and sex matched controls. A previously validated questionnaire, including demographic data, education, data on exposures, previous diseases, family history and habits, was administered.

Results:

In multivariate logistic regression analysis, it was found that history of work in construction sites was the strongest predictor of PD risk, followed by exposure to pesticides. In contrast, there was a negative association with smoking and history of mechanical factory employment. When the same statistical analysis was limited to association of PD with smoking, pesticides and construction work, the latter was found to be the strongest risk factor.

Conclusion:

The risk factors for PD in this population are work on a construction site and exposure to pesticides.

Résumé:

RÉSUMÉ:Introduction:

Depuis quelques années, on a observé une prévalence accrue de la maladie de Parkinson (MP) dans le sud de l'état d'Israël. Le but de cette étude était de déterminer à quels agents les patients avaient été exposés et s'il existait une association avec la MP dans la population urbaine de cette région.

Méthodes:

Quatre-vingt-trois patients atteints de MPet vivant en région urbaine ont été comparés à 93 contrôles appariés pour l'âge et le sexe. Un questionnaire validé comprenant des données démographiques, la scolarité, des données sur l'exposition à différents agents, les maladies antérieures, l'histoire familiale et les habitudes de vie leur a été administré.

Résultats:

l'analyse de régression logistique multivariée a montré que le fait d'avoir déjà travaillé dans des chantiers de construction était le meilleur prédicteur du risque de MP, suivi de l'exposition aux pesticides. Par contre, il existait une association négative avec le tabagisme et le travail en usine. Quand l'analyse était limitée à l'association de MP avec le tabagisme, l'exposition à des pesticides et le travail dans un chantier de construction, ce dernier étant le plus grand facteur de risque. Les patients nés dans l'ancienne Union Soviétique étaient plus souvent atteints d'ulcère peptique.

Conclusion:

Les facteurs de risque de la MP dans cette population sont le travail dans un chantier de construction et l'exposition à des pesticides.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 28 , Issue 2 , May 2001 , pp. 144 - 147
Copyright
Copyright © The Canadian Journal of Neurological 2001

References

REFERENCES

1. Herishanu, YO, Goldsmith, JR, Abarbanel, JM, Weinbaum, Z. Clustering of Parkinson’s disease in southern Israel. Can J Neurol Sci 1989;16:402–405.Google Scholar
2. Herishanu, YO, Kordysh, E, Goldsmith, JR. A case-referent study of extrapyramidal signs (preparkinsonism) in several rural communities of southern Israel. Can J Neurol Sci 1998;25:127–133.Google Scholar
3. Goldsmith, JR, Herishanu, YO, Podgaietski, M, Kordysh, E. Dynamics of parkinsonism and Parkinson’s disease in residents of adjacent kibbutzim in Israel’s Negev. Environ Res 1997;73:156–161.Google Scholar
4. Hubble, JP, Cao, T, Hassanein, RES, Neuberger, JS, Koller, WC. Risk factors for Parkinson’s disease. Neurology 1993;43:1693–1697.Google Scholar
5. Semchuk, KM, Love, EJ, Lee, RG. Parkinson’s disease and exposure to agricultural work and pesticide chemicals. Neurology 1992;42:1328–1335.Google Scholar
6. Semchuk, KM, Love, EJ, Lee, RG. Parkinson’s disease: a test of the multifactorial etiologic hypothesis. Neurology 1993;43:1173–1180.Google Scholar
7. Butterfield, PG, Valanis, BG, Spencer, PS, Lindeman, CA, Nutt, JG. Environmental antecedents of young-onset Parkinson’s disease. Neurology 1993;43:1150–1158.Google Scholar
8. Seidler, A, Hellenbrand, W, Robra, BP, et al. Possible environmental, occupational, and other etiologic factors for Parkinson’s disease: a case-control study in Germany. Neurology 1996;46:1275–1284.Google Scholar
9. Rajput, AH, Uitti, RJ, Stern, W, et al. Geography, drinking water chemistry, pesticides and herbicides and the etiology of Parkinson’s disease. Can J Neurol Sci 1987;14(Suppl 3):414–418.Google Scholar
10. Tanner, CM, Chen, B, Wang, W, et al. Environmental factors in the etiology of Parkinson’s disease. Can J Neurol Sci 1987; 14 (Suppl 3):419–423.Google Scholar
11. Ho, SC, Woo, J, Lee, CM. Epidemiologic study of Parkinson’s disease in Hong-Kong. Neurology 1989; 39:1314–1318.Google Scholar
12. Marder, K, Logroscino, G, Alfaro, B, et al. Environmental risk factors for Parkinson’s disease in an urban multiethnic community. Neurology 1998; 50:279–281.Google Scholar
13. Barbeau, A, Roy, M, Cloutier, T, Plasse, T, Paris, S. Environmental and genetic factors in the etiology of Parkinson’s disease: Advances in Neurology, Volume 48. New York: Raven Press, 1988; 299–306.Google Scholar
14. Tanner, CM, Chen, B, Peng, M, et al. Environmental factors and Parkinson’s disease: a case-control study in China. Neurology 1989; 39: 660–664.Google Scholar
15. Morano, A, Jimenez-Jimenez, FJ, Molina, JA, Antolin, MA. Risk-factors for Parkinson’s disease: case-control study in the province of Caceres, Spain. Acta Neurol Scand 1994; 89:164–170.CrossRefGoogle ScholarPubMed
16. Wechsler, LS, Checkoway, H, Franklin, GM, Costa, LG. A pilot study of occupational and environmental risk factors for Parkinson’s disease. Neurotoxicology 1991;12:387–392.Google Scholar
17. Duvoisin, RC, Gearing, FR, Schweitzer, M, Yahr, MD. A family study of parkinsonism. In: Barbeau, A, Brunette, JR. eds. Progress in Neuro-genetics. Amsterdam: Excerpta Medica. 1969;492–496.Google Scholar
18. Barbeau, A, Roy, M. Familial subsets in idiopathic Parkinson’s disease. Can J Neurol Sci 1984; 11: 144–150.Google Scholar
19. Jimenez-Jinenez, FJ, Mateo, D, Gimenez-Roldan, S. Premorbid smoking, alcohol-drinking and coffee consumption in Parkinson’s disease. A case-control study. Mov Disord 1992;7: 339–344.Google Scholar
20. Golbe, LI, Cody, RA, Duvoisin, RC. Smoking and Parkinson’s disease. Search for a dose-response relationship. Arch Neurol 1986; 43: 774–778.Google Scholar
21. Hellenbrand, W, Seidler, A, Robra, BP, et al. Smoking and Parkinson’s disease: a case-control study in Germany. Int J Epidemiol 1997; 26: 328–339.Google Scholar
22. Kessler, II. Epidemiologic studies of Parkinson’s disease. A community based survey. Am J Epidemiol 1972; 96: 242–245.Google Scholar