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An Update on the Cellular and Molecular Biology of Brain Tumors

Published online by Cambridge University Press:  18 September 2015

Michael D. Cusimano
Michael D. Cusimano*
Affiliation:
Division of Neuropathology, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
*
Chief Resident, Division of Neurosurgery, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
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Abstract:

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Patients with tumors of the central nervous system (CNS) remain difficult to treat despite recent advances in surgical, chemotherapeutic and radiotherapeutic techniques. A better understanding of the molecular and cellular biology of neoplasia is providing neuroscientists with a framework on which to devise novel therapies for these patients. It thus becomes imperative that neurologists and neurosurgeons be aware of these advances in basic science that may eventually have a positive impact on patient management. This paper reviews our present knowledge of the process of CNS oncogenesis and the roles that chemicals, viruses, oncogenes, growth inhibitor genes, and growth factors play in the process.

Type
Special Features
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue 1 , February 1989 , pp. 22 - 27
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

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