Hostname: page-component-848d4c4894-xm8r8 Total loading time: 0 Render date: 2024-06-25T14:50:39.341Z Has data issue: false hasContentIssue false
  • English
  • Français

Vitamin C synthesis in rats fed on diets deficient or normal in iron content

Published online by Cambridge University Press:  09 March 2007

R. Rajalakshmi ,
G. Subbulakshmi  and
Tara Mehta
R. Rajalakshmi
Affiliation:
Departments of Foods and Nutrition and Biochemistry, M.S. University, Baroda, India
G. Subbulakshmi
Affiliation:
Departments of Foods and Nutrition and Biochemistry, M.S. University, Baroda, India
Tara Mehta
Affiliation:
Departments of Foods and Nutrition and Biochemistry, M.S. University, Baroda, India
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Iron deficiency was induced in albino rats by a milk-powder diet. Control groups were given milk powder plus an iron source.

2. The haemoglobin content of the blood was determined once each month. When the haemoglobin level fell to 10 g/100 ml or less in the deficient animals, determinations were made of the vitamin C content of 24 h urine as well as of liver, kidney, adrenals, brain and blood. Additional studies were made of in vitro synthesis of the vitamin by liver homogenate.

3. The urine and tissues of the deficient animals were found to have a higher concentration of the vitamin than those of the control animals. The difference in enzyme synthesis was in the same direction, but was not statistically significant.

4. The results are interpreted as suggesting an increased requirement, by rats, of the vitamin in iron deficiency; this increased requirement is met by increased synthesis.

Type
Research Article
Information
British Journal of Nutrition , Volume 21 , Issue 2 , May 1967 , pp. 333 - 340
Copyright
Copyright © The Nutrition Society 1967

References

Bagchi, K. & Chowdhury, S. (1954). Indian J. med. Sci. 8, 856.Google Scholar
Burns, J. J., Conney, A. H., Dayton, P. G., Evans, C., Martin, G. R. & Taller, D. (1960). J. Pharmac. exp. Ther. 129, 132.Google Scholar
Chandrasekhara, N., Rao, M. V. L. & Srinivasan, M. (1963). Proc. Soc. exp. Biol. Med. 112, 827.CrossRefGoogle Scholar
Chandrasekhara, N., Rao, M. V. L. & Srinivasan, M. (1965). Indian J. Biochem. 2, 44.Google Scholar
Chatterjee, I. B., Ghosh, N. C., Ghosh, J. J., Roy, R. N. & Guha, B. C. (1957). Sci. Cult. 23, 50.Google Scholar
Chatterjee, I. B. & McKee, R. W. (1965). Archs Biochem. Biophys. 109, 62.CrossRefGoogle Scholar
Dugal, L. P. (1961). Ann. N. Y. Acad. Sci. 92, 307.CrossRefGoogle Scholar
Dugal, L. P. & Frontier, G (1952). J. appl. Physiol. 5, 143. Quoted by Lloyd B. B. & Sinclair H. M. (1953) in Biochemistry and Physiology of Nutrition. Vol. 1, p. 453. Quoted by Lloyd, B.B. & Sinclair, H.M. (1953) in Biochemistry and Physiology of Nutrition. Vol 1, p. 453. [G.H., Bourne and G.W., Kidder, editors.] New York: Academic Press Inc.Google Scholar
Hawk, P. B., Oser, B. L. & Summerson, W. H. (1954). Practical Physiological Chemistry. London: J. and A. Churchill Ltd.Google Scholar
Minuto, N. & Luzzatto, L. (1957). Boll. Soc. ital. biol. Sper. 33, 1754. Quoted in Chem. Abstr. (1961) 55, 9597.Google Scholar
Monier, M. M., Byer, S. & Weiss, R. J. (1953). Fedn Proc. Fedn Am. Socs exp. Biol. 12, 248.Google Scholar
Moore, C. V., Arrowsmith, W. R., Welch, J. & Minnich, V. (1939). J. clin. Invest. 18, 553.CrossRefGoogle Scholar
Page, E. & Babineau, L. N. (1950). Can. J. Res. 28E, 196. Quoted by Lloyd, B. B. & Sinclair, H. M. (1953) in Biochemistry and Physiology of Nutrition. Vol. 1, p. 437. [ G. H. Bourne and G. W. Kidder, editors.] New York: Academic Press Inc.CrossRefGoogle Scholar
Roe, J. H. & Kuether, C. A. (1943). J. biol. Chem. 147, 399.CrossRefGoogle Scholar
Schultze, M. O. (1950). J. Nutr. 41, 103.CrossRefGoogle Scholar
Stirpe, F., Comporti, M. & Caprino, G. (1963). Biochern. J. 86, 232.CrossRefGoogle Scholar
Sure, B., Theis, R. M. & Harrelson, R. T. (1939). J. biol. Chem. 129, 245.CrossRefGoogle Scholar
Terroine, T. (1960). In World Review of Nutrition and Dietetics. [Bourne, G. H., editor.] Vol. 2, p. 105. London: Pitman Medical Publishing Co. Ltd.Google Scholar
Wintrobe, M. M. (1958). Clinical Hematology. Philadelphia: Lea and Febiger.Google Scholar
Yanovskaya, B. I. (1952). Biokhimiya 17, 414. Quoted in Chem. Abstr. (1953) 47, 718.Google Scholar