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Studies of the action of vitamin D in the rat

Published online by Cambridge University Press:  09 March 2007

Elisabeth M. Cheesman  and
Alice M. Copping
Elisabeth M. Cheesman
Affiliation:
Departments of Physiology and Nutrition, Queen Elizabeth College, University of London, Campden Hill Road, London, W 8
Alice M. Copping
Affiliation:
Departments of Physiology and Nutrition, Queen Elizabeth College, University of London, Campden Hill Road, London, W 8
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Abstract

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1. Rats were given a rachitogenic diet for 28 days; some were dosed with vitamin D 2 or 3 days before they were killed and some received vitamin D throughout the experiment.

2. Parathyroid leucine aminopeptidase was measured histochemically as an index of parathyroid activity and silver impregnation as a criterion of bone calcification.

3. Calcium and phosphorus were estimated in bone ash and in serum. In rats killed 2 days after a single dose of vitamin D, increases were found in the Ca and P content of serum and bones and in epiphyseal Ca deposition. Parathyroid activity was decreased. In rats killed 3 days after a dose of vitamin D there was a marked increase in serum Ca and P but a less clear change in bone Ca and P although epiphyseal calcification was evident. The parathyroid activity was less than in rats dosed throughout the experiment.

Type
Research Article
Information
British Journal of Nutrition , Volume 23 , Issue 2 , June 1969 , pp. 371 - 375
Copyright
Copyright © The Nutrition Society 1969

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