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Prevention of retinoic acid-induced early craniofacial abnormalities by folinic acid and expression of endothelin-/HAND in the branchial arches in mouse

Published online by Cambridge University Press:  19 February 2008

Zhaofeng Zhang ,
Yajun Xu ,
Li Li ,
Jing Han ,
Liping Zheng ,
Peng Liu  and
Yong Li
Zhaofeng Zhang
Affiliation:
Department of Nutrition & Food Hygiene, Laboratory of Molecular Toxicology and Developmental Molecular Biology, School of Public Health, Peking University, Beijing 100083, P.R. China
Yajun Xu
Affiliation:
Department of Nutrition & Food Hygiene, Laboratory of Molecular Toxicology and Developmental Molecular Biology, School of Public Health, Peking University, Beijing 100083, P.R. China
Li Li
Affiliation:
Department of Nutrition & Food Hygiene, Laboratory of Molecular Toxicology and Developmental Molecular Biology, School of Public Health, Peking University, Beijing 100083, P.R. China
Jing Han
Affiliation:
Department of Nutrition & Food Hygiene, Laboratory of Molecular Toxicology and Developmental Molecular Biology, School of Public Health, Peking University, Beijing 100083, P.R. China
Liping Zheng
Affiliation:
Department of Nutrition & Food Hygiene, Laboratory of Molecular Toxicology and Developmental Molecular Biology, School of Public Health, Peking University, Beijing 100083, P.R. China
Peng Liu
Affiliation:
Department of Nutrition & Food Hygiene, Laboratory of Molecular Toxicology and Developmental Molecular Biology, School of Public Health, Peking University, Beijing 100083, P.R. China
Yong Li*
Affiliation:
Department of Nutrition & Food Hygiene, Laboratory of Molecular Toxicology and Developmental Molecular Biology, School of Public Health, Peking University, Beijing 100083, P.R. China
*
*Corresponding author: Professor Yong Li, fax +86 10 82801177, email liyong@bjmu.edu.cn
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Abstract

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Prevention of retinoic acid-induced craniofacial abnormalities by folinic acid, and endothelin-1 (ET-1)/dHAND protein and mRNA expression were investigated in mouse embryos using the whole embryo culture, streptavidin–biotin peroxidase complex method, and whole-mount in situ hybridization. In the whole embryo culture, 1·0 and 0·1mm-folinic acid dose dependently prevented branchial region malformations and decreased defects by 93% and 77%, respectively. Folinic acid at concentrations of 1·0 and 0·1mm significantly increased ET-1 and dHAND protein expression levels compared to retinoic acid-exposed values in embryonic branchial areas. Folinic acid also increased ET-1 and dHAND mRNA levels in the same region. The present results suggest that folinic acid may prevent retinoic acid-induced craniofacial abnormalities via increasing ET-1 and dHAND levels in the branchial region during the organogenic period.

Keywords

Branchial archdHANDEndothelin-1Folinic acidWhole embryo culture
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 3 , September 2006 , pp. 418 - 425
Copyright
Copyright © The Nutrition Society 2006

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